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| 联苯苄唑乳膏体外经皮透过评价试验 | |
| 引用本文： | 郜琪臻,刘慧,赵亚囡,丁平田. 联苯苄唑乳膏体外经皮透过评价试验[J]. 实用药物与临床, 2011, 14(1): 30-34 |
| 作者姓名： | 郜琪臻 刘慧 赵亚囡 丁平田 |
| 作者单位： | 1. 中国医科大学第一附属医院药学部,沈阳,110001 2. 济南三源药业有限公司,济南,250014 3. 沈阳药科大学药学院,沈阳,110016 |
| 摘 要： | 目的通过离体透过性试验,评估受试联苯苄唑乳膏透过安全性的大小。方法以小型猪全皮皮肤为模型,应用改良的Franz立式扩散池,分别采用生理盐水、PEG400:生理盐水(1:2)混合液为接受液,于1、2、3、4、6、8、10 h定时取样,利用HPLC测定药物浓度。结果对照联苯苄唑乳膏样品和受试样品在生理盐水接受液的条件下,均不能透过离体的小型猪皮肤。在PEG400:生理盐水(1:2)接收液条件下,有微量透过,10 h的累积透过量受试联苯苄唑乳膏为(0.286±0.100)μg/cm2,对照联苯苄唑乳膏为(0.269±0.033)μg/cm2,二者经皮透过曲线基本一致。结论受试联苯苄唑乳膏和对照联苯苄唑乳膏在药物透过安全性大小上具有一致性。 |
| 关 键 词： | 联苯苄唑乳膏 体外 透皮吸收 |
Study on percutaneous permeability of bifonazole creams |
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| GAO Qi-zhen,LIU Hui,ZHAO Ya-nan,DING Ping-tian. Study on percutaneous permeability of bifonazole creams[J]. Practical Pharmacy and Clinical Remedies, 2011, 14(1): 30-34 | |
| Authors: | GAO Qi-zhen LIU Hui ZHAO Ya-nan DING Ping-tian |
| Affiliation: | GAO Qi-zhen1,LIU Hui2,ZHAO Ya-nan3,DING Ping-tian3(1.Department of Pharmacy,The First Hospital of China Medical University,Shenyang 110001,China,2.Jinan Sanyuan Pharmaceutical Company,Jinan 250014,3.Shenyang Pharmaceutical University,Shenyang 110016,China) |
| Abstract: | Objective To evaluate the percutaneous permeability of bifonazole creams with miniature pig(the pama fragrant pig)full thickness skin as the model in modified franz diffusion cells. Methods Physiological saline solution and the PEG400:physiological saline solution(1:2)was used as receptor medium.The drug concentration in samples withdrawn at 1,2,3,4,6,8,10 h was determined by HPLC. Results Drug in the commercial product and test preparation could not diffuse across the excised miniature pig skin in physiolo... |
| Keywords: | Bifonazole creams In vitro Percutaneous permeability |
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