氯沙坦对肾病综合征肾小管功能保护作用的临床研究

目的研究氯沙坦对肾病综合征肾小管功能的保护作用。方法 60例患者随机分为2组,治疗组给予强的松联合氯沙坦,对照组给予强的松。治疗12周后,观察两组血清白蛋白(sAlb)、24 h尿蛋白定量(24hup)、尿N-乙酰-β-D氨基葡萄糖苷酶(uNAG)、尿视黄醇结合蛋白(uRBP)、尿比重(SG)。结果经治疗,两组sAlb水平增高与治疗前比较,差异有统计学意义(P<0.05),24hup、uNAG、uRBP等指标降低与治疗前比较,差异有统计学意义(P<0.05),其中以治疗组24hup、uNAG、uRBP水平下降最为明显,与对照组比较,差异有统计学意义(P<0.05)。结论氯沙坦对肾病综合征肾小管功能具有保护作用。

Protective effects of losartan on renal tubular of patients with nephrotic syndrome

Objective To study the effects of losartan on renal function of patients with nephrotic syndrome. Methods 60 patients were randomly divided into two groups,patients of treatment group were given prednisone and losartan,patients of control group received prednisone,after 12 weeks of treatment,the serum albumin(sAlb),24 h urinary protein(24hup),urinary N-acetyl-β-D-glucosaminidase(uNAG),urinary retinol-binding protein(uRBP),urine specific gravity(SG)were observed. Results After treatment,both groups' sAlb level increased(P<0.05),24hup,uNAG,uRBP and other indicators decreased(P<0.05),in which the decrease of 24hup,uNAG,uRBP of treatment group were more obvious than those of control group(P<0.05). Conclusion Losartan has protective effect on renal function of patients with nephrotic syndrome.