油质性软膏制剂供试液制备方法的研究

目的：用4种配比溶剂制备凡士林基质的软膏制剂供试液，比较它们溶解或乳化软膏制剂的性能。并考察它们对金黄色葡萄球菌CMCC（B）26003）]及铜绿假单胞菌CMCC（B）10104]的抑菌作用。方法：以不同配比的溶剂，溶解或乳化供试品。结论：十四烷酸异丙酯溶解凡干林基质性能最好；司盘-805g、单硬脂酸甘油酯3g、聚山梨酯8010g。司盘-8010g、单硬脂酸甘油酯6g、聚山梨酯8020g的配方乳化凡士林基质较差。

Research on Preparing Method for Testing Solution of Oleiferous Ointment Preparation

Objectives: To prepare the ointment preparation for testing solution of vaseline basis prerared by four matching ways, comparing their properties of dissolving or emulsifying the ointment preparation, and ispecting the bacteriostatic effects of staphylococ-cus aureusCMCC(B)26003] pseudomnas aeruginosaCMCC(B) 10104]. Method: The solutions for testing were dissolved or emulsified in different matching solvent. Conclusion: The property of vaseline basis dissolved with isopropyl myristate is best, plysorbate 80, sorbitanmono-oleate 80, monoslearate glycerol and polysorbate with liquid paraffin are next, the mixture with polysorbate 80 (20g), sorbitanmono 80(10g) and monostearate glycerol(6g) are less effective.