Single-dose ciprofloxacin versus 3 days of norfloxacin in uncomplicated urinary tract infections in women |
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| Authors: | F. Auquer,F. Cordó n,E. Gorina,J. C. Caballero,C. Adalid,J. Batlle, the Urinary Tract Infection Study Group |
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| Affiliation: | Subdivisiód'AtencióPrimària, Institut Catalàde la Salut, Unitat Docent de Medicina de Família i Comunitària, c/Santa Clara, 33–35 Girona 17001,Spain;Medical Department, Q.F. Bayer S.A. Barcelona,;Garraf Primary Rural Health Area, Barcelona, Spain;Microbiology Laboratory, 'Josep Trueta' Hospital, Girona, Spain;Tel: +34 972 20 00 04 Fax: +34 972 20 39 18 E-mail: |
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| Abstract: | A double-blind, randomized controlled study to evaluate the efficacy and safety of a single dose of 500 mg of ciprofloxacin versus 3 days 400 mg twice-daily of norfloxacin in uncomplicated urinary tract infection in women was designed. Patients underwent four visits: baseline, and at 3, 7 and 28 days. The main efficacy variables were clinical and microbiological outcome at day 7. Analyses on both valid patients and intention-to-treat populations were performed. Two hundred and twenty-six patients (114 receiving ciprofloxacin and 112 receiving norfloxacin) were considered valid for efficacy evaluation. Bacteriologic cure was 91.2% in the ciprofloxacin group and 91.9% in the norfloxacin group. Clinical resolution was 91.2 and 93.8%, respectively. Both treatments were equally efficacious ( P = 0.016). |
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| Keywords: | ciprofloxacin norfloxacin urinary tract infection |
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