屏哮饮对哮喘小鼠细胞因子影响

目的：观察屏哮饮对哮喘小鼠IL-4、IL-10、IFN-γ的影响。方法：采用ELISA法观察哮喘小鼠支气管肺泡灌洗液（BALF）中IL-4、IL-10、IFN-γ的表达。结果：屏哮饮低高剂量组IL-10、IFN-γ显著高于模型组及孟鲁司特钠组,差异有统计学意义,IL-4显著低于模型组,差异有统计学意义。结论：屏哮饮可通过上调IFN-γ表达,一定程度上调IL-10表达,抑制IL-4表达,达到抑制气道炎症、延缓气道重塑的作用。

Effect of Pingxiao Decoction on Cytokines of Asthmatic Mice

Objective：To evaluate the effect of Pingxiao Decoction on IL-4, IL-10 and IFN-γ of asthmatic mice. Methods：ELISA was used to observe the expressions of IL-4, IL-10 and IFN- γin asthmatic mice bronehoalveolar lavage fluid （BALF）. Results ： The expressions of IL-10 and IFN-γ of Pingxiao Decoction low and high dose groups were significantly higher than those of the model group and the montelukast group, and the difference was statistically significant. The expression of IL-4 of Pingxiao Decoction low and high dose group was significantly lower than that of the model group, and the difference was statistically significant. Conclusion：Pingxiao Decoction can suppress airway inflammation, and delay airway remodeling. The effect can be accomplished by increasing expression of IFN- γ , to some extent increase expression of IL-10 and inhibit the expression of IL-4.