香砂六君丸治疗脾胃虚弱型糖尿病胃轻瘫疗效观察

目的：观察香砂六君丸治疗脾胃虚弱型糖尿病胃轻瘫（DiabeticGastroparesis,DGP）的临床疗效。方法：将60例脾胃虚弱型糖尿病胃轻瘫患者随机分为治疗组和对照组,各30例。在降糖药物控制血糖的基础上,治疗组予香砂六君丸每日3次,每次8粒,对照组予多潘立酮片口服10mg/次,每日3次,于餐前30min口服,用药疗程均为4周。观察两组患者的疗效以及治疗前后主要症状、中医证候积分、胃排空率。结果：治疗组总有效率（93.34%）明显优于对照组总有效率（73.3%）,差异具有统计学意义（P〈0.05）;两组治疗后餐后饱胀、食欲减退、嗳气、中医证候积分均有所改善,与治疗前比较差异有统计学意义（P〈0.05）;治疗组治疗后与对照组比较,饱胀、食欲减退、嗳气、中医证候积分差异有统计学意义（P〈0.01）。两组患者用药前后血糖、肝肾功能均无异常,也未见不良反应发生。结论：香砂六君丸可以有效改善脾胃虚弱型糖尿病胃轻瘫患者临床症状,促进患者胃排空率。

Observation of Clinical Effect of Xiangsha Liujunzi Pill on Treating Diabetic Gastroparesis due to Weakness of Spleen and Stomach

Objective： To observe the clinical effect of Xiangsha Liujunzi Pill on treating diabetic gastroparesis due to the weakness of spleen and stomach. Methods： A randomized controlled clinical trial was carried out. Sixty patients were randomly divided into control group and treatment group. The treatment group （ n=30 ） were given Xiangsha Liujunzi Pill, three times a day ; the control group （ n=30 ） was treated with Domperidone orally 10 mg per day, three times a day. The clinical effect and changes of syndrome score of traditional Chinese medicine and gastric emptying rate were observed before and after treatment. Results ： The total effective rate in treatment group （ 93.34% ）was higher than that in control group （ 73.3%, P〈0.05 ）. Syndrome score of traditional Chinese medicine after treatment was decreased as compared with those before treatment in two groups （ P〈0.05 ）. Conclusion ： Xiangsha Liujunzi Pill can improve symptoms status of diabetic gastroparesis with weakness of spleen and stomach, enhance gastric emptying rate and has no adverse effect.