扶正消积分期治疗方案对结肠癌患者生存期的影响

目的：观察扶正消积分期治疗方案对结肠癌患者生存期的影响。方法：采用回顾性队列研究方法，将218例Ⅱ-Ⅳ期结肠癌患者分为观察组159例和对照组59例；对照组给予规范西医治疗。治疗组在规范西医治疗基础上结合中医扶正消积分期治疗方案。通过随访，观察两组中位生存期（mOS）、无疾病生存期（DFS）、无进展生存期（PFS）及复发转移率。结果：①中位生存期：观察组mOS未达到中位死亡人数，对照组为57．6月，两组比较差异有统计学意义（P〈0．05）；②DFS：观察组DFS未达到中位死亡人数，对照组为48个月，两组比较差异有统计学意义（P〈0．05）；③PFS：IV期病例PFS，观察组为24个月，对照组为14．4个月，两组比较差异无统计学意义（P〉0．05）；④复发转移率：Ⅱ期病例观察组复发转移率为2．4％，对照组为25％;III期病例观察组复发转移率为14．0％，对照组为48．6％；两组Ⅱ期、Ⅲ期病例复发转移率比较均有统计学差异（P〈0．05）。结论：扶正消积分期治疗方案可有效延长结肠癌患者的生存期、无疾病生存期，并降低复发转移率。

Therapeutic Regimen on Colon Cancer Lifetime by Strengthening Healthy Qi and Eliminating Stagnation at Different Stages

Objective： To observe the effect of therapeutic regimen on lifetime colon cancer by strengthening healthy qi and eliminating stagnation at different stages. Methods： By retrospective cohort study, 218 cases with colon cancer at stage II- IV were divided into observation group （159 cases） and control group （59 cases）. The cases in control group were treated with western medicine, and cases in treatment group were treated with Chinese therapeutic regimen additionally. The median survival time （MOS）, disease-free survival （DFS）, progression-free survival （PFS） and recurrence rate were observed by follow-up visit. Results： （1） Median survival time： the death number had not yet reached the median death number in observation group, and it was 57.6 months in control group, with a significant difference between the two groups （ P 〈 0.05 ） ; （2） DFS： the death number had not yet reached the median death number in observation group, and it was 48 months in control group, with a significant difference between the two groups （P 〈 0.05 ） ; （3）PFS ： cases at IV stage, its progression-free survival was 24 months in observation and 14. 4 months in control group, without significant difference between the two groups （P 〉 0.05 ） ; （4）recurrenee rate： cases at stage II , its recurrence rate was 2.4% in observation and was 25% in control group ; cases at stage III, its recurrence rate was 14.0% in observation group and was 48.6% in control group ; with significant differences between the two groups at stage II or III （ p 〈 0. 05 ）. Conclusion： The therapeutic regimen of strengthening healthy qi and eliminating stagnation can prolong the lifetime and disease-free survival time and reduce the recurrence rate effectively.