Clonal cytotoxic T cells in myeloma |
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| Authors: | Sze Daniel M Y Brown Ross D Yuen Edna Gibson John Ho Joy Raitakari Maria Basten Antony Joshua Douglas E Fazekas de St Groth Barbara |
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| Affiliation: | a Institute of Haematology NSW Royal Prince Alfred Hospital Camperdown Australia.b The Department of Clinical Chemistry Turku University Central Hospital Turku Finland.c Centenary Institute of Cancer Medicine and Cell Biology NSW Newtown Australia. |
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| Abstract: | Multiple myeloma (MM) is a malignant disease characterized by accumulation of morphologically recognizable plasma cells producing immunoglobulin (Ig) in the bone marrow. The occurrence of clonal T cells in MM, as defined by the presence of rearrangements in the T-cell receptor (TCR)-beta chains detected on Southern blotting, is associated with an improved prognosis. This review aims to describe the various ways in which we have demonstrated the presence of such T cell clones, and to describe the phenotype of these cells. Finally, the specificities of these clinically important CD8+ T cell populations will be discussed in the context of immunotherapy. |
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| Keywords: | Multiple Myeloma T Cell Expansions Idiotype Immunotherapy |
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