The blood–brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates—Evidence from in vivo neuroimaging studies |
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| Authors: | Arnar Astradsson Bruce G. Jenkins Ji-Kyung Choi Penelope J. Hallett Michele A. Levesque Jack S. McDowell Anna-Liisa Brownell Roger D. Spealman Ole Isacson |
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| Affiliation: | aHarvard University and McLean Hospital, NINDS Udall Parkinson's Disease Research Center of Excellence, Belmont, MA, USA;bMassachusetts General Hospital (MGH) Nuclear Magnetic Resonance Center, Athinoula A. Martinos Center for Biomedical Imaging, Boston, MA, USA;cMGH Positron Emission Tomography Center, Massachusetts General Hospital, Boston, MA, USA;dNew England Primate Research Center, Harvard Medical School, Southborough, MA, USA |
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| Abstract: | It has been suggested, based on rodent studies, that levodopa (l-dopa) induced dyskinesia is associated with a disrupted blood–brain barrier (BBB). We have investigated BBB integrity with in vivo neuroimaging techniques in six 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) lesioned primates exhibiting l-dopa-induced dyskinesia. Magnetic resonance imaging (MRI) performed before and after injection of Gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) revealed an intact BBB in the basal ganglia showing that l-dopa-induced dyskinesia is not associated with a disrupted BBB in this model. |
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| Keywords: | Levodopa Dyskinesia Primates Blood– brain barrier Imaging Gadolinium-DTPA |
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