Immunotoxic changes associated with a 7-day oral exposure to perfluorooctanesulfonate (PFOS) in adult male C57BL/6 mice |
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Authors: | Li Zheng Guang-Hui Dong Yi-He Jin Qin-Cheng He |
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Institution: | (1) School of Public Health, China Medical University, North 2nd Road, Heping Districts, 110001 Shenyang, People’s Republic of China;(2) Department of Environmental Science and Technology, Dalian University of Technology, 116024 Dalian, People’s Republic of China;(3) Department of Immunology, China Medical University, 110001 Shenyang, People’s Republic of China |
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Abstract: | Perfluorooctanesulfonate (PFOS) is a widespread contaminant in the environment, as well as in wildlife and in humans. Toxicity
tests in rodents have raised concerns about potential developmental, reproductive, and systemic effects of PFOS. However,
there is little information about the effect of PFOS on immune system. In this study, adult male C57BL/6 mice were given by
gavage 0, 5, 20 or 40 mg PFOS/kg day−1 for 7 days. The results showed that PFOS exposure decreased food intake and body weight and increased liver mass and serum
corticosterone levels in a dose-dependent manner. Flow cytometry analysis showed that the number of lymphocytic subpopulation
cells decreased significantly in 20 or 40 mg PFOS/kg day−1 group in comparison with normal C57BL/6 mice. Treatment with PFOS also markedly depressed the natural killer (NK) cell activity,
lymphocyte proliferation and the plaque-forming cell (PFC) response. These results indicate that PFOS exposure can affect
the immunity function in mice. |
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Keywords: | Perfluorooctanesulfonate Lymphocyte proliferation Immunity function |
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