Growth hormone deficiency and growth hormone therapy in Ullrich-Turner-Syndrome |
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Authors: | O. Butenandt |
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Affiliation: | (1) Universitäts-Kinderklinik München, Germany |
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Abstract: | Summary In a girl with Ullrich-Turner-Syndrome (gonadal dysgenesis 45, XO) and growth hormone deficiency, 10 U of human growth hormone/m2 body surface area/week increased the growth rate from 2.0 to 4.1 cm/year. Doses of up to 36 U/m2/week did not improve the growth rate in 4 girls with Ullrich-Turner-Syndrome who had normal plasma growth hormone concentration and incretion. We conclude that growth hormone therapy is unsuccessful in dwarfism in Ullrich-Turner-Syndrome and should be reserved for patients with proven growth hormone deficiency.Supported by Deutsche Forschungsgemeinschaft, SFB 51/C10 |
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Keywords: | Ullrich-Turner-Syndrome Growth hormone deficiency Growth hormone therapy |
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