| 2型糖尿病相关线粒体ND1基因的荟萃分析 |
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| 引用本文： | 陈静,万钢,冯洁,张建佚,相蕾,齐科研,孙亮,史晓红,唐雷,霍正浩,杨泽.2型糖尿病相关线粒体ND1基因的荟萃分析[J].中国心血管杂志,2009,14(4). |
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| 作者姓名： | 陈静 万钢 冯洁 张建佚 相蕾 齐科研 孙亮 史晓红 唐雷 霍正浩 杨泽 |
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| 作者单位： | 1. 宁夏医科大学医学遗传与细胞生物学教研室,银川,750004
2. 卫生部北京医院卫生部北京老年医学研究所 |
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| 摘 要： | 目的利用荟萃分析评价线粒体NDI基因点突变与2型糖尿病发病的相关性。方法通过文献检索收集1999年1月至2008年9月在中英文公共数据库检索或已经发表的线粒体NDl基因点突变与2型糖尿病相关的病例对照研究。按照本研究纳入和排除标准,筛选线粒体NDl基因G3316A、T3394C 2个点突变作为研究对象。应用STATA 9.0 SE软件对各研究进行综合分析。结果在病例对照研究中,线粒体G3316A、T3394C相对危险度合并OR值和95%CI分别为:2.70(1.39～5.24)、3.44(1.41～8.40)。结论线粒体G3316A、T3394C点突变可能与中国人2型糖尿病遗传易感性相关。
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| 关 键 词： | 糖尿病 2型 线粒体 基因 疾病遗传易感性 |
A meta-analysis of the relationship between mitochondrial DNA NDI gene polymorphisms and type 2 diabetes in Chinese people |
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| CHEN Jing,WAN Gang,FENG Jie,ZHANG Jian-yi,XIANG Lei,QI Ke-yan,SUN Liang,SHI Xiao-hong,TANG Lei,HUO Zheng-hao,YANG Ze.A meta-analysis of the relationship between mitochondrial DNA NDI gene polymorphisms and type 2 diabetes in Chinese people[J].Chinese Journal of Cardiovascular Medicine,2009,14(4). |
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| Authors: | CHEN Jing WAN Gang FENG Jie ZHANG Jian-yi XIANG Lei QI Ke-yan SUN Liang SHI Xiao-hong TANG Lei HUO Zheng-hao YANG Ze |
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| Abstract: | Objective To evaluate the relationships between mitochondrial DNA ND1 gene polymorphisms and type 2 diabetes in Chinese people.Methods Domestic case-control studies published from Jan 1999 to September 2008 were reviewed and analyzed by Meta analysis.According to the inclusion and exclusion criteria,mitochondrial DNA G3316A and T3394C polymorphisms were selected to analyse by STATA9.0SE statistical program in this study.Results In case-control studies,the odds ratio(OR) values and 95% confidence interval(CI) of mitochondrial G3316A and T3394C were 2.70 (1.39-5.24) and 3.44 (1.41-8.40) respectively.Conclusion Mitochondrial G3316A and T3394C polymorphisms may be the susceptible risk factors of type 2 diabetes in Chinese people. |
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| Keywords: | Diabetes mellitus type 2 Mitochondria Genes Genetic predisposition to disease |
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