西安地区汉族成年健康男性年龄与血清前列腺特异性抗原的关系

目的 探讨中国汉族成年健康男性年龄血清前列腺特异性抗原(PSA)参考值。方法 应用酶联免疫法测定了1096名23～85岁健康男性血清tPSA、fPSA及fPSA／tPSA的比值。应用直线相关统计学方法分析年龄与PSA水平的相关性。结果中国汉族成年健康男性年龄特异性血清PsA参考值分别为：20～29岁1．20μg／L、3039岁1．21μg／L、40～49岁1．23μg／L、50～59岁2．35μg／L、60～69岁3．20μg／L和70岁以上者3．39μg／L。经直线相关统计学分析年龄与PSA水平存在相关性。与其他种族年龄特异性血清PSA参考值进行比较,发现中国汉族成年健康男性各年龄组年龄特异性血清PSA参考值不但显著低于欧美国家的黑种人和白种人,而且也低于同属黄种人的日本人和韩国人。结论中国汉族成年健康男性年龄血清PSA参考值明显低于黑种人、白种人,甚至低于同属黄种人的日本人和韩国人。了解中国健康成年男性血清PSA正常值和年龄特异性血清PSA参考值对临床有一定的指导意义。

Age-specific reference ranges for serum prostate-specific antigen in Chinese men

OBJECTIVE: To evaluate the age-specific reference ranges for serum prostate-specific antigen in Chinese men. METHODS: Serum tPSA and fPSA were measured by enzyme-linked immunosorbent assay (ELISA) and fPSA/tPSA ratio was calculated in 1,096 health Chinese men of 23 - 85 years old. The relationship between age and PSA indexes was analyzed with simple linear regression. RESULTS: The recommended age-specific reference range (95th percentile) for serum PSA for Chinese were: 1.20 microg/L for 20-29 years; 1.21microg/L for 30-39 years; 1.23 microg/L for 40-49 years; 2.35 microg/L for 50-59 years; 3.20 microg/L for 60-69 years; 3.39 microg/L for >or= 70 years. The serum PSA concentration correlated directly with age. The age-specific reference range was lower for Chinese men than not only for white and black men, but also for Japanese and Koreans men. CONCLUSION: The age-specific reference ranges for serum PSA are lower significantly for Chinese men than for black, white men, even for Japanese and Koreans men. Study the normal upper limit of PSA and the age-specific reference ranges for serum prostate-specific antigen in Chinese men is very important.