真性红细胞增多症合并肺癌广泛转移一例报告并文献复习

回顾分析1例真性红细胞增多症(polycythemia vera,PV)合并肺癌广泛转移病例的诊治过程。经血常规、骨髓等确诊为PV的63岁男性患者,给予羟基脲化疗5年后,合并肺癌广泛转移。先后经含吉西他滨加铂类、紫杉醇加铂类药方案治疗均无效,改用吉非替尼(Iressa)后,病情好转。初步研究结果提示,细胞遗传学的异常、癌基因的存在,以及抗代谢药(羟基脲等)损伤染色体,产生异常的克隆,可能是发生第二肿瘤的原因。单药Iressa对常规化疗无效者,仍可起到一定的疗效。肿瘤防治杂志,2005,12(19):1510-1512

One case report of polycythemia vera companied with lung cancer widespread transfer and literature review

The objective of this paper was to analyse retrospectively one case of polycythemia vera companied with lung cancer widespread transfer on diagnosis and treatment course. The patient, male, 63 years old, with polycythemia vera, received hydroxyurea for 5 years,then companied with lung cancer. It is ineffective to use gemcitabine in addition to cisplatinu and paclitaxel plus cisplatinu, and after using iressa, the state of illness was taken a turn for the better.In conclusion, the abnormal clone, induced by cytogenetics abnormity, oncogene and chromatosome damnification caused by antimetabolite yield, may be a reason of occurrence of second tumor. Iressa produces still some effective results after routine chemotherapy is of inefficiency.