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Coexpression of intermediate-sized filaments in sialadenoma papilliferum and other salivary gland neoplasms
Authors:Akiyo Nakahata  Hiroyo Deguchi  Tetsuo Yanagawa  Hideo Yoshida  Mitsunobu Sato  Yoshio Hayashi
Affiliation:Department of Oral Pathology, Tokushima University School of Dentistry, Japan.
Abstract:The neoplastic cells present in a sialadenoma pappiliferum were found by immunoperoxidase method and immunofluorescent staining technique to co-express 3 different types of intermediate-sized filaments (IFs) defined by monoclonal antibodies to cytokeratin, vimentin and desmin. When other salivary gland tumors such as 18 pleomorphic adenomas, 15 adenolymphomas, 2 oxyphilic adenomas, 7 mucoepidermoid tumors, 5 acinic cell tumors, 8 adenoid cystic carcinomas and 6 adenocarcinomas were examined immunohistochemically for the expression of IFs, no tumors with all 3 types of IFs observed in sialadenoma papilliferum were found.
Keywords:intermediate filament    salivary gland tumors    sialadenoma papilliferum
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