EB病毒抗体检测对儿童传染性单核细胞增多症的诊断价值

目的对传染性单核细胞增多症（IM）的三种实验室诊断方法进行比较,以寻求一种对IM快速诊断的实验方法。方法对162例临床诊断为IM患儿的血常规、异型淋巴细胞分类计数（AL）、血清嗜异性抗体（HA）及EB病毒抗体（EBV-CA-IgM和EBV-CA-IgG）的敏感性进行比较,分析三种实验室诊断方法正确识别IM的能力。结果 IM患儿外周血AL阳性率41.4%,HA阳性率43.8%,EBV-VCA-IgM阳性率87.7%,EBV-CA-IgG阳性率59.9%,EBV-CA-IgM诊断IM敏感性显著高于AL与HA（2χ分别为75.83,69.08,P〈0.01）。结论 EBV-CA抗体检测对于早期诊断IM具有十分重要的意义,而且方法简便快速,适宜在基层医院开展。

Diagnostic value of the detection of EB virus antibody in children with infectious mononucleosis

Objective To compare three Methods of laboratory diagnosis of infectious mononucleosis（IM） to explore a method for rapid diagnosis of infectious mononucleosis.Methods We compared the Results of routine blood test,atypical lymphocyte（AL）,heterophile antibody（AH） and EB virus antibody（EBV-CA-IgM and EBV-CA-IgG） of 162 cases of IM to analyze the capacity of three Methods of laboratory diagnosis for identifying IM.Results In the children with IM,the incidence of AL in peripheral blood was 41.4%,the incidence of HA was 43.8%,the incidence of EBV-VCA-IgM was 87.7%,and the incidence of EBV-CA-IgG was 59.9%.The sensitivity of EBV-CA-IgM was significantly higher than AL（x2=75.83,P0.01）and HA（x2=69.08,P0.01） EBV-CA-IgG in diagnosis of IM.Conclusion Detection of EB virus antibody is of great importance for early diagnosis of IM.It is fast and convenient,which is suitable for the basic hospitals.