尼莫地平、银杏叶滴丸及复方血栓通片治疗非痴呆型血管性认知功能障碍疗效比较

目的：比较非痴呆型血管性认知功能障碍(VCIND)患者分别服用尼莫地平、银杏叶滴丸及复方血栓通片的临床治疗效果。方法纳入120例高要市中医院2014年6月1日至2015年5月31日期间收治的VCIND患者。将所有患者按随机数字表法分为三组各40例。其中A组采用尼莫地平治疗，B组采用银杏叶滴丸治疗，C组采用复方血栓通片治疗。三组患者均治疗6个月，观察三组患者的超敏C反应蛋白(hs-CRP)水平、大脑及椎底动脉血流流速、认知功能、精神状况和日常生活能力。结果治疗前三组患者的hs-CRP水平、大脑及椎底动脉血流流速比较差异均无统计学意义(P>0.05)；治疗后C组患者的hs-CRP水平、大脑及椎底动脉血流流速均明显优于A、B两组，差异均有统计学意义(P<0.05)；治疗前三组患者的蒙特利尔认知评估量表(MoCA)、精神简易量表(MMSE)以及日常生活能力(ADL)评分比较差异均无统计学意义(P>0.05)；治疗后C组患者的MoCA、MMSE以及ADL评分均明显高于A、B两组，差异均有统计学意义(P<0.05)。结论复方血栓通对VCIND患者脑血管再通更佳，血流速度更快，认知功能、精神状态以及日常生活能力改善更显著，值得临床推广应用。

Comparison on the efficacy of nimodipine,Ginkgo biloba leaf drop pill and compound thrombus in the treatment of vascular cognitive impairment without dementia

Objective To compare the clinical therapeutic effect of nimodipine, Ginkgo leaf dripping pills and compound thrombus in the treatment of patients with vascular cognitive impairment without dementia (VCIND). Methods A total of 120 cases of VCIND patients, who admitted to the hospital from June 1, 2014 to May 31, 2015, were included and randomly divided into three groups according to the random number table method, with 40 cases in each group. A group, B group and C group were respectively treated with nimodipine treatment, Ginkgo biloba pills treat-ment and compound thrombosis for six months. The high sensitivity C reactive protein (hs-CRP) level, blood flow veloc-ity of brain and bottom of the vertebral artery, cognitive function, mental state and ability of daily life of these three groups were observed. Results There was no difference in the levels of hs-CRP and blood flow between the three groups before treatment (P>0.05). The levels of hs-CRP and blood flow in the C group were significantly better than the other two groups (P<0.05). There were no differences in Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE) and Activities of Daily Living (ADL) scores between the three groups before treatment (P>0.05). The MoCA, MMSE and ADL scores were significantly higher in C group than in the other two groups (P<0.05). Conclusion Compound thrombosis has the better curative effect on the blood flow rate, cognitive function, mental state and ability of daily life in patients with VCIND, which is worthy of clinical application and promotion.