硫酸镁联合硝苯地平治疗妊娠期高血压的疗效及其对患者尿液蛋白质的影响

目的：探讨硫酸镁联合硝苯地平治疗妊娠期高血压的疗效及其对患者尿液蛋白质的影响。方法将我院妇产科2014年1月至2015年12月收治的110例妊娠期高血压患者按照数字表法随机分为观察组和对照组，每组55例。对照组患者单独给予硫酸镁治疗，观察组患者给予硫酸镁联合硝苯地平治疗，4周为一个疗程。比较两组患者的临床治疗效果、血流动力学和尿蛋白水平的变化。结果观察组患者的临床治疗有效率为94.5%(52/55)，明显高于对照组的81.8%(45/55)，差异有统计学意义(P<0.05)；治疗后，观察组患者的舒张压为(90.3±20.1) mmHg，明显低于对照组的(102.1±20.4) mmHg，差异有统计学意义(P<0.05)；治疗后，观察组患者24 h尿蛋白、尿钙黏蛋白、尿激肽原1分别为(473.1±36.6) mg、(2.41±0.93) mg/L、(446.10±140.13) mg/L，均显著低于对照组的(831.1±29.4) mg、(3.39±1.10) mg/L、(508.35±136.02) mg/L，差异均有显著统计学意义(P<0.01)。结论硫酸镁联合硝苯地平治疗妊娠期高血压可以有效改善治疗效果，降低血液黏度并影响尿蛋白。

Effect of magnesium sulfate combined with nifedipine on urine protein in patients with pregnancy induced hypertension

Objective To investigate the effect of magnesium sulfate combined with nifedipine on urine pro-tein in patients with pregnancy induced hypertension. Methods A total of 110 patients with hypertension, who were ad-mitted to the Department of Obstetrics and Gynecology in our hospital from January 2014 to December 2015, were ran-domly divided into observation group and control group according to number table, with 55 cases in each group. Patients in the control group were given magnesium sulfate alone, and those in the observation group were treated with magne-sium sulfate combined with nifedipine treatment, one month as a course. The clinical effect, blood flow dynamics and urine protein levels of the two groups were compared. Results The clinical therapeutic effect of the observation group was 94.5%(52/55), which was significantly better than 81.8%(45/55) in the control group (P<0.05). After treatment, dia-stolic pressure was (90.3±20.1) mmHg in the observation group, which was significantly lower than (102.1±20.4) mmHg in the control group (P<0.05);The 24 h urinary protein, urine cadherin and urine kininogen 1 in the observation group were respectively (473.1 ± 36.6) mg, (2.41 ± 0.93) mg/L, (446.10 ± 140.13) mg/L, which were significantly lower than (831.1±29.4) mg, (3.39±1.10) mg/L, (508.35±136.02) mg/L in the control group (P<0.01). Conclusion In the treatment of hypertension in pregnancy, the combination of magnesium sulfate and nifedipine, as compared with magnesium sul-fate alone, can effectively reduce the blood viscosity and urinary protein.