EV71病毒感染手足口病合并神经系统损害的MRI研究进展

手足口病(HFMD)是由多种肠道病毒引起的传染性疾病，好发于学龄前儿童。其主要传播途径为消化道、呼吸道以及密切接触；主要临床表现为发热，口腔和四肢末端的斑丘疹、疱疹，重者可引起多种神经系统并发症，如脑干脑炎、无菌性脑膜炎、急性驰缓性麻痹(AFP)等，致残率和病死率高。因此，早期诊断手足口病并发神经系统损害，制定治疗方案以及治疗效果的评估对降低重症手足口病病死率、致残率具有重要意义，而磁共振(MRI)是目前监测HFMD并发神经系统损害的有效手段。本文就手足口病并神经系统损害的MRI研究进展做一简要综述。

MRI findings of enterovirus 71-infected hand,foot and mouth disease complicated with neurological impairment

Hand, foot and mouth disease (HFMD) is an infectious disease caused by multiple enterovirus, which mostly happens in preschool children, and is mainly transmitted by routes of digestive tract, respiratory tract and close contact. The major clinical manifestations include fever, rash in mouth and extremities, herpes, and various neuro-logical complications in severe cases, such as encephalitis in brain stem, aseptic meningitis, acute flaccid paralysis (AFP), which result in high morbidity and mortality. Therefore, to diagnose HFMD with neurological complications ear-lier, to establish a treatment plan, and to assess the therapeutic effect are significant for reducing the mortality and mor-bidity. MRI is nowadays an effective method to investigate HFMD with neurological complications. The research prog-ress of MRI regarding HFMD complicated with neurological impairment were reviewed as follows.