CAF方案和CTF方案治疗中晚期乳腺癌的疗效观察

目的 比较CAF和CTF方案治疗晚期乳腺癌的疗效和毒副作用。方法 97例Ⅲ～Ⅳ期乳腺癌患者被随机分为2组,A组53例,用含阿霉素(ADM)的CAF方案治疗4～6周期;B组44例,用含吡柔比星(THP)的CTF方案治疗4～6周期。结果 A组CR 5例,PR 23例,有效率53.8％;B组CR 5例,PR 20例,有效率56.8％。两组疗效差异无显著性(P>0.05)。不良反应中白细胞下降率,两组差异无显著性(P>0.05),胃肠道反应发生率两组差异有显著性(P<0.05),脱发及心脏毒副反应发生率两组差异有显著性(P<0.01)。结论 CTF方案疗效与CAF方案相当,但患者更易耐受,特别是脱发和累积性心脏毒副反应要远低于CAF方案,因此THP治疗晚期乳腺癌患者是高效、安全的。

The clinical study of combination chemotherapy with CAF and CTF for advanced and recurrent breast cancers

Objective To compare the therapeutic and adverse effects between combination chemotherapy regimens CAF and CTF in the treatment of advanced or recurrent breast cancer. Methods Ninty-seven patients with advanced or recurrent breast cancer were randomly divided into two groups: 53 patients in the group A treated with the adriamycin (ADM)-based combination therapy CAF and other 44 patients in the group B treated with the pirarubicin (THP)-based combination therapy CTF. The number of cycles given was 4 to 6. Results Fifty-two patients in group A were evaluable for toxicity and efficacy.44 patients in group B were evaluable for toxicity and efficacy. The response rate (RR) was 53.83% in the group A and 56.82% in the group B with no significant differ-ence( P > 0.05). Leukopenia was not significantly different between two groups (P > 0.05). Gastrointestinal disorders were significantly different between two groups ( P < 0.01) . Conclusion The favorable response to CTF was equivalent to that to CAF, but it causes lower frequency of alopecia and heart toxicity. The THP-based combination therapy is effective in treating metastatic breast cancer has less severe toxicity.