| 冷暴露大白鼠血浆中冷凝蛋白的含量测定及其分离鉴定 |
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| 引用本文： | 何子安,孙方人.冷暴露大白鼠血浆中冷凝蛋白的含量测定及其分离鉴定[J].解放军预防医学杂志,1996,14(4):257-260. |
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| 作者姓名： | 何子安 孙方人 |
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| 作者单位： | 军事医学科学院卫生学环境医学研究所 |
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| 摘 要： | 本文测定了冷暴露条件下离体的，在体的和局部冻伤的大白鼠血浆中冷凝蛋白（ＣＩＰ）的含量，结果表明低温和局部冻伤均可促使血浆中ＣＩＰ含量显著高。实验结果提示ＣＩＰＯ一种冷致性水不溶的大分子蛋白质，可能是一类与纤维粘连蛋白（ｆｉｂｒｏｎｅｃｔｉｎ）有关的蛋白。推想血浆中ＣＩＰ过量形成可能是导致冻伤组织血液循环障碍，形成徽因栓的原因之一。
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| 关 键 词： | 冷凝蛋白 冷暴露 血浆 分离鉴定 |
ISOLATION,DETERMINATION AND CHARACTERIZATION OF COLD INSOLUBLE PROTEINS(CIP)FROM PLASMA OF RATS AFTER COLD EXPOSURE |
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| He Zian,Sun Fangren,Ma Zimin.ISOLATION,DETERMINATION AND CHARACTERIZATION OF COLD INSOLUBLE PROTEINS(CIP)FROM PLASMA OF RATS AFTER COLD EXPOSURE[J].Journal of Preventive Medicine of Chinese People's Liberation Army,1996,14(4):257-260. |
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| Authors: | He Zian Sun Fangren Ma Zimin |
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| Abstract: | n this study,the cold-insoluble proteins(CIP)formed in rat plasma after cold stresswere determined,isolated and characterized.It is suggested that cold stimulation can in-crease the content of CIP in rat plasma significantly.CIP is a water-insoluble proteinwith large molecular weight,possibly a complex related to fibronectin(Fn ).CIP in plasmamay be one of the factors causing micro thrombi and blocking blood circulation in the cold in-jured tissues. |
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| Keywords: | cold insoluble proteins cold exposure plasma isolation and characteri-zation |
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