Potentiation of the hCRF-induced release of ACTH in man by an opioid antagonist |
| |
Authors: | H Ehrenreich Ch Kolmar O A Müller F -D Goebel |
| |
Institution: | (1) Medizinische Poliklinik and Medizinische Klinik Innenstadt, Universität München, Germany |
| |
Abstract: | Summary Administration of synthetic human corticotropin-releasing factor (hCRF; 2 µg/kg body weight) to six normal male subjects produced a significant rise in plasma ACTH, followed by an increase in circulating cortisol. Simultaneous treatment with the opioid antagonist naloxone (1.6 mg i.v. bolus, followed by an infusion at a rate of 1.2 mg/h) significantly potentiated the hCRF-induced rise in ACTH and enhanced the cortisol response to hCRF. It is suggested that naloxone acts by antagonizing an inhibitory ultra-short-loop feedback effect of coreleased -endorphin on pituitary corticotrophs, thereby amplifying the net effect of hCRF, i.e., the release of ACTH.ACTH
adrenocorticotropic hormone
- CRF
corticotropin-releasing factor
- hCRF
human CRF
- oCRF
ovine CRF
- EKG
electrocardiogram
- POMC
proopiomelanocortin
- RIA
radioimmunoassay
- S.E.M.
standard error of the mean
This study was supported by the Deutsche Forschungsgemeinschaft (Go 299/3-2; Mu 585/2-2) |
| |
Keywords: | Human corticotropin-releasing factor (hCRF) ACTH Cortisol Naloxone Opioid receptor blockade |
本文献已被 SpringerLink 等数据库收录! |