| The Effects of Etimicin and Gentamicin on Renal Endoplasmic Reticulum ~(45)Ca~(2 )-Uptake and Ca~(2 )-Mg~(2 )-ATPase Activity |
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| 作者姓名： | 李忠东 洪文清 李培忠 |
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| 作者单位： | 空军总医院药理科，军事医学科学院毒物药物研究所 |
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| 摘 要： | 目的：研究爱大霉素和庆大霉素对大鼠肾皮质内质网４５Ｃａ２＋摄取以及对内质网膜上Ｃａ２＋Ｍｇ２＋ＡＴＰａｓｅ活性的影响。方法：４５Ｃａ２＋示踪技术和孔雀蓝分光光度法。结果：爱大霉素和庆大霉素在大于或等于３．４×１０４ｍｏｌ·Ｌ１时，能抑制内质网４５Ｃａ２＋摄取（抑制率分别大于或等于１７．４％和２５．５％）；在３．４×１０２ｍｏｌ·Ｌ１时，对内质网膜上Ｃａ２＋Ｍｇ２＋ＡＴＰａｓｅ活性有抑制作用（抑制率分别为２４．１７％和２９．１９％）。结论：爱大霉素和庆大霉素在较高浓度时可使胞浆钙升高，这可能与其产生肾毒性有关
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| 关 键 词： | 爱大霉素 庆大霉素 肾皮质内质网 ~(45)Ca~(2＋)-摄取 Ca~(2＋)-Mg~(2＋)-ATPase |
The Effects of Etimicin and Gentamicin on Renal Endoplasmic Reticulum ~(45) Ca ~(2 ) Uptake and Ca~(2 ) Mg~(2 ) ATPase Activity |
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| Zhong Dong Li ,Wen Qing Hong and Pei Zhong Li.The Effects of Etimicin and Gentamicin on Renal Endoplasmic Reticulum ~(45)Ca~(2 )-Uptake and Ca~(2 )-Mg~(2 )-ATPase Activity[J].Journal of Chinese Pharmaceutical Sciences,1998(3). |
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| Authors: | Zhong Dong Li Wen Qing Hong and Pei Zhong Li |
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| Institution: | Zhong Dong Li 1,Wen Qing Hong 2 and Pei Zhong Li 2 1. Department of Clinical Pharmacology,General Hospital of Air Force,Beijing 100036, 2. Institute of Toxicology and Pharmacology,Academy of Military Medical Science,Beijing100850 Rece |
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| Abstract: | |
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| Keywords: | Etimicin (EM) Gentamicin (GM) Endoplasmic reticulum 45 Ca 2 uptake Ca 2 Mg 2 ATPase |
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