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代谢组学在中药毒性质量标志物研究中的应用及展望
引用本文:Peng-jie Zhang,Ya-mei Li,Ya-ni Zhang,Wei Huang,Yu-bo Li,Yan-jun Zhang,Chang-xiao Liu b. 代谢组学在中药毒性质量标志物研究中的应用及展望[J]. 中草药(英文版), 2018, 10(2): 108-115. DOI: 10.1016/j.chmed.2018.02.001
作者姓名:Peng-jie Zhang  Ya-mei Li  Ya-ni Zhang  Wei Huang  Yu-bo Li  Yan-jun Zhang  Chang-xiao Liu b
作者单位:a State Key Laboratory of Modern Chinese Medicine, School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, Chinab State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China,a State Key Laboratory of Modern Chinese Medicine, School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, Chinab State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300194, China,a State Key Laboratory of Modern Chinese Medicine, School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, Chinab State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300195, China,a State Key Laboratory of Modern Chinese Medicine, School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, Chinab State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300196, China,a State Key Laboratory of Modern Chinese Medicine, School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, Chinab State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300197, China,a State Key Laboratory of Modern Chinese Medicine, School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, Chinab State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300198, China,b State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China.
摘    要:鉴于中药质量评价指标与中药有效性及安全性相脱节的问题,刘昌孝院士提出中药质量标志物的概念,为完善中药质量控制方法提供一条新的思路。中药毒性的早期预测、中药毒性质量标志物的发现、中药毒性质量标志物的形成以及中药毒性质量标志物的易感性,这是中药毒性质量标志物的几个关键环节。作为与机体毒性表型最接近的系统生物学方法,代谢组学在中药毒性质量标志物研究中具有独特的优势。本文将从四方面进行阐释:1.代谢组学结合模式识别等技术,建立中药毒性整体预测模型,即代谢组学在中药毒性预测的应用;2.从中药物质成分分析、中药毒性质量标志物初筛、中药毒性质量标志物验证、毒性机制的阐释出发,阐释代谢组学在中药毒性质量标志物中发现中的应用;3.从中药质量标志物的生源途径分析、植物次生代谢产物研究出发,综述代谢组学在中药毒性质量标志物形成中的应用;4.从中药导致的靶器官毒性易感性出发,阐释毒性生物标志物的关键靶点及代谢途径,最终明确“有毒”中药毒性质量标志物的易感机制,即代谢组学在中药毒性质量标志物易感性研究中的应用。借助于代谢组学技术,有助于系统地、全面地发现与中药安全性相关的质量控制指标,这为临床“有毒”中药的合理应用提供有效的保证。

关 键 词:代谢组学;毒性质量标志物;中药
收稿时间:2017-11-23

Application and Prospect of Toxicity Quality Markers of Traditional Chinese Medicine based on Metabolomics
Peng-jie Zhang,Ya-mei Li,Ya-ni Zhang,Wei Huang,Yu-bo Li,Yan-jun Zhang a and Chang-xiao Liu b. Application and Prospect of Toxicity Quality Markers of Traditional Chinese Medicine based on Metabolomics[J]. Chinese Herbal Medicines, 2018, 10(2): 108-115. DOI: 10.1016/j.chmed.2018.02.001
Authors:Peng-jie Zhang  Ya-mei Li  Ya-ni Zhang  Wei Huang  Yu-bo Li  Yan-jun Zhang a  Chang-xiao Liu b
Affiliation:1. State Key Laboratory of Modern Chinese Medicine, School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;2. State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China
Abstract:In view of the problem that the quality evaluation indicators divorced from effectiveness and safety in Chinese materia medica (CMM), Prof. Chang-xiao Liu et al have put forward a concept of quality markers (Q-markers) of CMM, which provided a new thought for improving the CMM quality control method. The toxicity Q-markers of CMM are described as follows, the early toxicity prediction of CMM, the discovery, formation and susceptibility research of toxicity Q-markers of CMM. Metabolomics is a systematic biology approach, closely related to the toxicity phenotype of organism, has unique advantages in toxicity Q-markers research. The toxicity Q-markers of CMM are explained from the following four aspects in this review: 1) the establishment of toxicity prediction model of CMM, which is based on metabolomics, pattern recognition, and other techniques; 2) the discovery of toxicity Q-markers of CMM based on metabolomic, which is meaning that the toxicity Q-markers are interpreted regarding to the chemical composition analysis of CMM, preliminary screening and verification of the toxicity Q-markers and toxicity mechanism research; 3) the research on the formation of toxicity Q-markers based on metabolomics, which is described from biosynthetic pathway analysis and the secondary metabolites analysis of toxicity Q-markers; and 4) the susceptibility study of toxicity Q-markers based on metabolomics, namely, the key targets, and metabolic pathways of toxicity Q-markers are explained according to the target organ toxicity susceptibility caused by CMM, and then the toxicity susceptibility mechanism of CMM is clarified. Therefore, the application of metabolomics helps to systematically and comprehensively discover the quality control indicators related to the CMM safety, which further provides a rational evidence for the clinical application of toxicity of CMM.
Keywords:metabolomics  toxicity Q-markers  Chinese materia medica
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