| 脂蛋白（a）对血管内皮细胞损伤作用的实验研究 |
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| 引用本文： | 赵满仓 贾艳岩. 脂蛋白（a）对血管内皮细胞损伤作用的实验研究[J]. 河北医药, 2000, 22(1): 12-14 |
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| 作者姓名： | 赵满仓 贾艳岩 |
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| 作者单位： | 中国人民解放军467医院(赵满仓!050081河北省石家庄市，贾艳岩!050081河北省石家庄市)，河北省血液中心(谢志坚) |
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| 摘 要： | 目的 研究脂蛋白（ａ）「Ｌｐ（ａ）」对血管内皮细胞（ＥＣ）的损伤作用和高密度脂蛋（ＨＤＬ）存在时对血管ＥＣ的损伤作用。方法 以体外培养的人脐静脉ＥＣ为模型，通过观察细胞形态、测定细胞功能了解Ｌｐ（ａ）和ＨＤＬ和Ｌｐ（ａ）对ＥＣ的损伤作用。结果 预加入ＨＤＬ再加入定量的Ｌｐ（ａ）后，ＥＣ收缩，胞浆呈分支状，乳酸脱氟酶（ＬＤＨ）释放量增高，６－酮－前列腺素Ｆｌａ（６－ｋｅｔｏ－ＰＧＦｌａ）合成明显关少
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| 关 键 词： | 内皮细胞 脂蛋白（a） 高密度脂蛋白 动脉硬化 |
Experimental study on damaging effect of lipoprotein(a) on endothelial cells (EC) of blood vessel |
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| Abstract: | Objective To study the damaging effect of lipoprotein (a) [Lp(a)] with and without high density lipoprotein (HDL) on EC. Methods Cells of human umbilical veins cultured in vitro were taken as a model and the damaging effect of Lp (a) and Lp (a) HDL on EC was evaluated by observing cell morphology and determing cell functions. Results HDL Lp(a) can cause contraction on EC and ramification of cytoplasm,increase of lactic dehydrogenase (LDH) release,and decrease synthesis of 6 keto PGFla.There is not marked difference between HDL Lp(a) and LDL Lp(a). Conclusion Lp(a) has obviously damaging effect on EC,and HDL can not antagonize it's effect. |
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| Keywords: | endothelicyte (EC) lipo rotein(a) [Lp(a)] high density lipoprotein |
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