| 三草方不同极性部位及其配伍后对人肺腺癌SPC-A-1细胞的影响研究 |
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| 引用本文： | 邵振中,贾晓斌,陈彦,封亮,施峰. 三草方不同极性部位及其配伍后对人肺腺癌SPC-A-1细胞的影响研究[J]. 中国药房, 2010, 0(7): 581-583 |
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| 作者姓名： | 邵振中 贾晓斌 陈彦 封亮 施峰 |
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| 作者单位： | 江苏省中医药研究院中药新型给药系统重点实验室/国家中医药管理局中药口服释药系统重点研究室;江苏大学药学院; |
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| 基金项目： | 江苏省中医药领军人才项目(2006); 江苏省自然科学基金资助项目(BK2006155) |
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| 摘 要： | 目的:研究三草方的不同极性部位及其配伍后对人肺腺癌SPC-A-1细胞增殖活性的影响,筛选出最有效的抗癌部位,确定最合适的配伍方案。方法:采用醇提取法和水提取法分别制备三草方的95%、60%、30%醇提部位、水提部位和复方水煎液;以MTT法测定水煎液和各不同极性部位及其配伍后对人肺腺癌SPC-A-1细胞增殖活性的影响。结果:在三草方各极性部位中,60%醇提部位对人肺腺癌SPC-A-1细胞的IC50最低;60%和95%醇提部位配伍后有明显的协同抑瘤活性。结论:三草方95%和60%醇提部位之间的配伍为最合适的配伍方案;三草方的脂溶性部位具有良好的抗肺癌应用前景。
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| 关 键 词： | 三草方 极性部位 配伍 人肺腺癌SPC-A-1细胞 |
Study on the Effect of Various Polarity Fractions Extracted from Sancaofang and Its Combination on Human Lung Adencarcinoma SPC-A-1 Cells |
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| SHAO Zhen-zhong,JIA Xiao-bin,CHEN Yan,FENG Liang,SHI Feng SHAO Zhen-Zhong,JIA Xiao-bin. Study on the Effect of Various Polarity Fractions Extracted from Sancaofang and Its Combination on Human Lung Adencarcinoma SPC-A-1 Cells[J]. China Pharmacy, 2010, 0(7): 581-583 |
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| Authors: | SHAO Zhen-zhong JIA Xiao-bin CHEN Yan FENG Liang SHI Feng SHAO Zhen-Zhong JIA Xiao-bin |
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| Affiliation: | SHAO Zhen-zhong,JIA Xiao-bin,CHEN Yan,FENG Liang,SHI Feng(Key Laboratory of New Drug Delivery System of Chinese Meteria Medica,Jiangsu Provincial Academy of Chinese Medicine,Key Laboratory of Drug Release System of Oral TCM,State Administration of Traditional Chinese Medicine,Nanjing 210028,China) SHAO Zhen-Zhong,JIA Xiao-bin(College of Pharmacy,Jiangsu University,Zhenjiang 212013,China) |
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| Abstract: | OBJECTIVE: To study the effect of various polarity fractions extracted from Sancaofang (SCF) and its combination on proliferation of human lung adenocarciaoma SPC-A-1 cells for bolting the most effective position of anti-tumor and suitable compatibility regimes.METHODS: Ethanol extraction and water extraction were adopted to prepare 95%,60% and 30% ethanol extract portion,water extract portion of SCF and compound decoction.The MTT assay was used to determine the effect of various polarity fractions of SCF,d... |
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| Keywords: | Sancaofang Polarity fraction Compatibility SPC-A-1 cells |
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