| 硒化亚麻酸的抗癌作用研究 |
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| 引用本文： | 薛少安,吕登仕.硒化亚麻酸的抗癌作用研究[J].营养学报,1992,14(4):363-367. |
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| 作者姓名： | 薛少安 吕登仕 |
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| 作者单位： | 陕西师范大学化学系，榆林地区中医院，陕西省肿瘤防治研究办公室，陕西师范大学化学系，第四军医大学药理教研室 西安 710062，西安 710062 |
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| 摘 要： | 用作者首次合成的硒化亚麻酸进行动物体内外抗癌活性实验,结果表明:小鼠腹腔注射200mg·kg~(-1)·d~(-1)硒化亚麻酸乳剂(82)时,小鼠S_(180)实体瘤的抑制率为42.6％(P<0.01),对荷ARS腹水瘤小鼠的治愈率达75％,生命延长率达132％(P<0.01);在体外250μg/ml的浓度下,硒化亚麻酸对小鼠S_(180)腹水型瘤细胞的杀伤作用也明显高于亚麻酸。这些结果提示,硒化亚麻酸具有较强的抗癌作用。
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| 关 键 词： | 硒化亚麻酸 抗肿瘤 |
STUDIES ON THE ANTITUMOR EFFECT OF LINOLENIC ACID CONTAINING SELENIUM |
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| Xue Shaoan,Lu Dengshi,Yang Zhixue,Li Baolin,Tao Jingyi.STUDIES ON THE ANTITUMOR EFFECT OF LINOLENIC ACID CONTAINING SELENIUM[J].Acta Nutrimenta Sinica,1992,14(4):363-367. |
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| Authors: | Xue Shaoan Lu Dengshi Yang Zhixue Li Baolin Tao Jingyi |
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| Abstract: | Linolenic acid containing selenium was synthesized and brought into emul- sion(82). Its aatitumor effects were tested in vitro and in vivo. As a result, when 82 was injected peritoneally into mice(200mg·kg-1·d-1), its inhibitory rate on mouse S180 was 42.6%(P<0.01); its cure rate on the mice bearing ARS ascites tumor reached 75%, and its survival prolongation on the mice bearing ARS ascites tumor reached 132%(P<0.01). The in vitro antitumor effect of linolenic acid containing selenium is also much stronger than that of linolenic acid at the concentration of 250μg/ml. These results showed that linolenic acid containing selenium bore obvious antitumor activity. |
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| Keywords: | linolenic acid containing selenjutn antitumor |
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