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| 茶黄素对Ox-LDL诱导单核-内皮细胞粘附作用影响的研究 | |
| 引用本文： | 吕虎,华萍,余继红,蒋显猷,冷和平. 茶黄素对Ox-LDL诱导单核-内皮细胞粘附作用影响的研究[J]. 中药材, 2005, 28(4): 304-306 |
| 作者姓名： | 吕虎 华萍 余继红 蒋显猷 冷和平 |
| 作者单位： | 1. 江西师范大学生命科学学院,南昌,330000 2. 江西医学院基础部,南昌,330000 3. 江西绿色制药有限公司,南昌,330027 |
| 基金项目： | 本文为"九五"科技攻关计划"1035"工程项目,项目编号:96-901-05-277 |
| 摘 要： | 采用硫酸铜诱导低密度脂蛋白(LDL)氧化,细胞粘附实验,细胞ELISA方法测定内皮细胞间粘附因子(ICAM-1)和血管内皮细胞粘附因子(VCAM-1)表达水平,研究了茶黄素(TFs)对氧化型低密度脂蛋白(Ox-LDL)损伤血管内皮细胞导致单核细胞粘附的影响.结果显示,茶黄素(TFs)能显著抑制由Ox-LDL诱导的单核细胞-血管内皮细胞粘附效应以及细胞间粘附因子(ICAM-1)和血管内皮细胞粘附因子(VCAM-1)的表达,并呈现浓度剂量正相关性.提示,TFs抑制ICAM-1和VCAM-1的表达是其抑制单核-内皮细胞粘附和抗动脉粥样硬化的作用机制之一. |
| 关 键 词： | 茶黄素 茶色素 内皮细胞 氧化型低密度脂蛋白 粘附 |
| 修稿时间： | 2004-11-22 |
Study on the Effect of Theaflavins on the Adhesion between Monocyte and Endothelial Cells |
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| Lü Hu,Hua Ping,Yu Jihong,Jiang Xianyou,Leng Heping. Study on the Effect of Theaflavins on the Adhesion between Monocyte and Endothelial Cells[J]. Journal of Chinese medicinal materials, 2005, 28(4): 304-306 | |
| Authors: | Lü Hu Hua Ping Yu Jihong Jiang Xianyou Leng Heping |
| Affiliation: | Life Science College of Jiangxi Normal University, Nanchang. |
| Abstract: | The effect of theaflavins (TFs) on the adhesion between monocyte and endothelial cells induced by oxidized low density lipoprotein was studied. The experiments of cells-adhesion,the cells ELISA were applied.The results showed that TFs could significantly inhibit the adhesion between monocyte and endothelial cells,and the expression of cell adhesion molecule (ICAM-1) and vescular cell adhesion molecule (VCAM-1).That maybe one of the mechanisms in antiatheroclerosis and antiadhesion between monocyte and endothelial cells. |
| Keywords: | Theaflavins Teapigments Endothelial cells Oxidized low density lipoprotein Adhesion |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |