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In vitro activity of protoanemonin, an antifungal agent |
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| Authors: | M L Martín L San Román A Domínguez |
| Affiliation: | Departamento de Fisiologia y Farmacología, Universidad de Salamanca, Spain. |
| Abstract: | Protoanemonin, the lactone of gamma-hydroxy-vinylacrylic acid, isolated from Pulsatilla alpina has in vitro activity against fungi. The MIC is 15 micrograms/ml and RNA inhibition seems to be the first target of the drug. The LD50 of protoanemonin in male Swiss albino mice was 190 mg/kg. |
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