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Pilomyxoid astrocytoma in the adult cerebellum
Affiliation:1. Department of Neurosurgery, Royal Melbourne Hospital, 300 Grattan Street, Parkville, VIC 3050, Australia;2. Department of Anatomical Pathology, Royal Melbourne Hospital, VIC, Australia;3. Department of Surgery, Royal Melbourne Hospital, University of Melbourne, VIC, Australia;1. Department of Neurological Surgery, The Neurological Institute, Columbia University, 710 West 168th Street, 4th floor, New York, NY 10032, USA;2. Department of Neurological Surgery, Miami University, Miami, FL, USA;1. Department of Clinical Neuroscience, Institute of Health Biosciences, Tokushima University Graduate School, 3-18-15, Kuramoto-cho, Tokushima 770-8503, Japan;2. Department of Radiology, Institute of Health Biosciences, Tokushima University Graduate School, Tokushima, Japan;1. Plummer Movement Disorders Center, Neurosciences Institute, Baylor Scott & White Hospital, 2401 S. 31st Street, Temple, TX 76508, USA;2. Department of Internal Medicine, Texas A&M Health Sciences Center, Temple, TX, USA;3. Mind-Body Medicine Research Laboratory, Department of Psychology and Neuroscience, Baylor University, Waco, TX, USA;4. Baylor Movement Disorders Center, Neurosciences Institute, Baylor Scott & White Healthcare, Dallas, TX, USA;5. Movement Disorders Program, Department of Neurology, University of South Carolina, Columbia, SC, USA;1. MultiCare Orthopedics & Sports Medicine, Puyallup, WA, USA;2. Department of Orthopaedic Surgery, Loma Linda University Medical Center, 11406 Loma Linda Drive, Suite 213, Loma Linda, CA 92354, USA;3. Department of Pharmaceutical Science, School of Pharmacy, Loma Linda University, CA, USA;4. Back and Sport Institute, Newport Beach, CA, USA;1. Department of Neurology, The First Affiliated Hospital of Harbin Medical University, No. 23, Youzheng Street, Nangang District, Harbin 150001, Heilongjiang, China;2. Department of Neurology, The People’s Hospital of Cangzhou, Cangzhou, China;3. Department of Neurology, The First Hospital of Harbin, Harbin, China;4. Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China;5. Department of Pathology, The First Hospital Affiliated of Harbin Medical University, Harbin, China
Abstract:Pilomyxoid astrocytoma (PMA) is a recently recognised World Health Organization (WHO) Grade II tumour that was previously characterised as a subtype of the WHO Grade I pilocytic astrocytoma (PA). PMA has a histological appearance distinct from PA and a poorer prognosis due to its greater propensity for local recurrence and cerebrospinal dissemination. Although originally considered a paediatric tumour involving mainly the hypothalamic and chiasmatic region, reports of the lesion occurring in the adult population and other areas of the neuroaxis are emerging. We review the literature on PMA within the adult population and present the first case of PMA in the cerebellum of an adult female.
Keywords:Adult  Cerebellum  Pilocytic astrocytoma  Pilomyxoid astrocytoma
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