Disseminated choroid plexus papillomas in adults: A case series and review of the literature |
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| Affiliation: | 1. Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA;2. Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202, USA;3. Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46202, USA;5. Departments of Neurosurgery and Otolaryngology, Mayo Clinic, Rochester, MN 55905, USA;1. Department of Neurology, University of Missouri in Columbia, Five Hospital Drive CE 537 DC 047.00, Columbia, MO 65212, USA;2. Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA;1. Department of Neurosurgery, University of California San Francisco, San Francisco, CA, USA;2. Department of Orthopedic Surgery, FLH Hospitals, Geneva, NY, USA;3. Department of Orthopedic Surgery, Crouse Hospital, Syracuse, NY, USA;1. Department of Orthopaedics, Jackson Memorial Hospital, University of Miami, Miami, FL;2. Max Biedermann Institute of Biomechanics, Mount Sinai Medical Center, Miami, FL;4. Ouellette Group, Miami, FL;3. Department of Orthopaedics, Washington University, St. Louis, MO;1. Department of Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA;2. Oklahoma Comprehensive Brain Tumor Center, University of Oklahoma Health Sciences Center, 1000 N. Lincoln Blvd., Suite 4000, Oklahoma City, OK, USA;1. Stephen E. and Catherine Pappas Center for Neuro-Oncology and Division of Hematology/Oncology, Department of Neurology, Massachusetts General Hospital Cancer Center, 55 Fruit Street/Y9E, Boston, MA 02114, USA;2. Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA;3. Harvard Medical School, Boston, MA, USA;4. Department of Neurosurgery, Stanford University, Palo Alto, CA, USA;5. University of Tokyo Hospital, Tokyo, Japan;6. Department of Pathology, Massachusetts General Hospital, Boston, MA, USA;1. Children’s Mercy, Division of Child Neurology, 2401 Gillham Road, Kansas City, MO 64108, USA;2. Children’s Mercy, Section of Neurosurgery, Department of Surgery, Kansas City, MO, USA |
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| Abstract: | Choroid plexus papillomas (CPPs) are uncommon, usually intraventricular, low-grade tumors, accounting for less than 1% of all intracranial neoplasms and 2–4% of brain tumors in children. Dissemination of CPPs to multiple levels of the neuraxis has been seldom observed. Thus far, only 26 adult patients have been reported in the English language literature. With some exceptions, disseminated CPPs have been observed in adults and involved multiple sites along the cerebrospinal fluid pathways. Occasionally, intraparenchymal extension has been documented, and secondary involvement of the suprasellar region has been reported in only five patients. Postoperative treatment of CPPs has not been standardized. Most recommended therapies have been extrapolated from a series of atypical papillomas or carcinomas of the choroid plexus in children. We herein report a series of three patients of disseminated choroid plexus papillomas providing additional insights into this relatively rare entity. |
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| Keywords: | Adults Choroid plexus papilloma Disseminated |
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