Myopathic changes detected by quantitative electromyography in patients with MuSK and AChR positive myasthenia gravis |
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| Affiliation: | 1. Neurology Clinic, Department for Neuromuscular Disorders, Clinical Center of Serbia, Dr Subotica 6, 11000 Belgrade, Serbia;2. Medical Faculty, Belgrade University, Belgrade, Serbia;1. Department of Neurology, Dong-A University College of Medicine, 3-ga Dongdaesin-dong, Seo-gu, Busan 602-715, Republic of Korea;2. Department of Neurology, Cerebrovascular Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea;3. Department of Neurology, Seoul Medical Center, Seoul, Republic of Korea;4. Department of Neurology, Soonchunhyang University College of Medicine, Seoul, Republic of Korea;5. Department of Neurology, Eulji General Hospital, Eulji University, Seoul, Republic of Korea;6. Department of Neurology, Eulji University Hospital, Eulji University, Daejeon, Republic of Korea;7. Department of Neurology, Jeju National University Hospital, Jeju, Republic of Korea;8. Department of Neurology, Chonnam National University Hospital, Gwangju, Republic of Korea;9. Department of Neurology, Ilsan Paik Hospital, Inje University, Goyang, Republic of Korea;10. Department of Neurology, Dongguk University, Ilsan Hospital, Goyang, Republic of Korea;11. Department of Neurology, Youngnam University Medical Center, Daegu, Republic of Korea;12. Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea;13. Department of Neurology, Hallym University College of Medicine, Anyang, Republic of Korea;1. Department of Clinical Neuroscience, Institute of Health Biosciences, Tokushima University Graduate School, 3-18-15, Kuramoto-cho, Tokushima 770-8503, Japan;2. Department of Radiology, Institute of Health Biosciences, Tokushima University Graduate School, Tokushima, Japan;1. Department of Neurology, Rhode Island Hospital, 593 Eddy St., Providence, RI 02903, USA;2. Warren Alpert Medical School, Brown University, 222 Richmond St., Providence, RI 02903, USA;3. Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA |
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| Abstract: | Myopathic changes are frequent a electrophysiological finding in patients with muscle specific tyrosine kinase (MuSK) positive myasthenia gravis (MG). The aim of this study was to explore the importance of quantitative electromyography (EMG) in the detection of myopathic changes in MuSK MG patients. Classical and quantitative EMG were performed in 31 MuSK and 28 acetylcholine receptor (AChR) positive MG patients, matched by sex, age, disease duration and severity. Classical EMG revealed the presence of myopathic changes more frequently in MuSK MG compared to AChR MG patients, especially in the facial muscles. Quantitative EMG registered myopathic lesions more frequently than classical EMG, but the frequency was similar between MuSK and AChR MG patients. Quantitative EMG revealed myopathic changes in the majority of both MuSK and AChR positive MG patients. This examination is sensitive, but it cannot be used to differentiate between MG patients belonging to the different disease groups. It should not be used in isolation. Rather, it should complement classical EMG in the detection of myopathic changes. |
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| Keywords: | Electrophysiology Multi-MUP analysis MuSK Myasthenia gravis Quantitative EMG Turns amplitude analysis |
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