Increased S-nitrosothiols are associated with spinal cord injury in multiple sclerosis |
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| Affiliation: | 1. Institute of Higher Nervous Activity & Neurophysiology RAS, Department of Functional Biochemistry of the Nervous System, Butlerov Street 5A, Moscow 117485, Russia;2. Research Center of Neurology Russian Academy of Medical Sciences, Neuroinfection Department, Moscow, Russia;1. Guangdong Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China;2. Department of Neurology, Shaanxi Provincial People’s Hospital, Xi’an 710068, China;3. Department of Neurology, Liuzhou Municipal Liutie Central Hospital, Liuzhou 545007, China;4. Department of Rehabilitation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China;1. Discovery Research, Suven Life Sciences Ltd., Hyderabad - 500 055, India;2. Department of Pharmaceutical Sciences, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, India;1. Department of Neurological Surgery, Montefiore Medical Center/Albert Einstein College of Medicine, United States;2. Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States;3. Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States;4. Department of Orthopedic Surgery, University of California Davis, Sacramento, CA, United States;5. Department of Neurosurgery, University of California San Francisco, San Francisco, CA, United States;6. Spine Surgery, Hospital for Special Surgery, New York City, NY, United States;7. Department of Orthopedic Surgery, Rocky Mountain Hospital for Children, Denver, CO, United States;1. Department of Pharmaceutical Technology, Faculty of Pharmacy, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland;2. Université de Lorraine, CITHEFOR EA3452 “Drug Targets, Formulation and Preclinical Assessment”, Faculté de Pharmacie, 5, rue A. Lebrun, F-54000 Nancy, France;1. Nationwide Children’s Hospital, Ohio State University, Division of Neurology, 700 Children’s Drive, Columbus, OH 43205, USA;2. Rush Medical College, Rush University, IL, USA;3. University of Illinois at Chicago, Department of Medical Education, IL, USA;4. University of Chicago, Department of Neurology, IL, USA;1. Department of Radiology, The Royal Melbourne Hospital, Parkville, VIC, Australia;2. Department of Radiology, The University of Melbourne, Parkville, VIC, Australia;3. Department of Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia;4. Monash Imaging, Monash Health, Clayton, Victoria, Australia |
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| Abstract: | Multiple sclerosis (MS) is an immune-mediated disorder associated with inflammation, demyelination and axonal damage. In search of potential biomarkers of spinal cord lesions in MS related to nitric oxide metabolites, we measured total nitrite and nitrate levels, and protein-bound nitrotyrosine and S-nitrosothiol concentrations in the serum of MS patients at different stages of the disease. Sixty-eight patients and 36 healthy volunteers were included in the study. Total nitrite and nitrate levels were augmented in relapsing-remitting MS, while increased S-nitrosothiol concentrations were found both in relapsing-remitting and secondary-progressive MS. Further analysis demonstrated that S-nitrosothiol levels were selectively increased in patients with spinal cord injury. The data suggest that high S-nitrosothiol concentration may be a potential serum biomarker for spinal cord injury in MS. |
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| Keywords: | Multiple sclerosis Nitric oxide S-nitrosothiols Spinal cord |
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