Recent progress in the development of ursolic acid derivatives as anti-diabetes and anti-cardiovascular agents |
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| Authors: | Yili Dai Linjun Sun Yan Tan Wenyu Xu Shu Liu Jing Zhou Yalin Hu Jieying Lin Xu Yao Pengbing Mi Xing Zheng |
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| Institution: | 1. Institute of Pharmacy and Pharmacology, Hengyang Medicinal School, University of South China, Hengyang, China;2. Department of Pharmacy, Hunan Vocational College of Science and Technology, Changsha, China |
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| Abstract: | Ursolic acid (UA) is a pentacyclic triterpenoid, which exhibits many biological activities, particularly in anti-cardiovascular and anti-diabetes. The further application of UA is greatly limited due to its low bioavailability and poor water solubility. Up to date, various UA derivatives have been designed to overcome these shortcomings. In this paper, the authors reviewed the development of UA derivatives as the anti-diabetes anti-cardiovascular reagents. |
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| Keywords: | anti-cardiovascular anti-diabetes ursolic acid derivatives |
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