Effect of endoscopic third ventriculostomy on cerebrospinal fluid pressure in the cerebral ventricles |
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| Affiliation: | 1. Faculty of Science and Engineering, Macquarie University, NSW, Australia;2. Neuroscience Research Australia, Randwick, NSW, Australia;3. Graduate School of Biomedical Engineering, University of New South Wales, NSW, Australia;4. Prince of Wales Clinical School, University of New South Wales, NSW, Australia;5. School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia;1. School of Life Sciences, University of Lincoln, Brayford Pool, Lincoln, LN6 7DL, United Kingdom;2. Medical Statistics, Plymouth University Peninsula Schools of Medicine and Dentistry, PL6 8BX, United Kingdom;3. Centre of Behaviour and Evolution, Institute of Neuroscience, Newcastle University, NE2 4HH, United Kingdom;4. Institute for Global Food Security, Queen''s University Belfast, Belfast, BT9 5BN, United Kingdom;5. School of Animal, Rural and Environmental Sciences, Nottingham Trent University, NG25 0QF, United Kingdom;6. Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, United Kingdom;1. Radiology Unit, Department of Digestive Disease and Internal Medicine, S. Orsola-Malpighi Hospital, Bologna, Italy;2. Department of Medical and Surgical Sciences, Alma Mater Studiorum – University of Bologna, Italy;3. Medical Physics Unit, Radiology Unit, S. Orsola-Malpighi Hospital, Bologna, Italy;1. Clinical Haematology Unit, Internal Medicine Department-Kasr Al Aini, Faculty of Medicine, Cairo University, Cairo, Egypt;2. Vascular Medicine Unit, Internal Medicine Department-Kasr Al Aini, Faculty of Medicine, Cairo University, Cairo, Egypt;3. Army Force College of Medicine, Cairo, Egypt |
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| Abstract: | We aimed to show how endoscopic third ventriculostomy (ETV) treatment may affect cerebrospinal fluid (CSF) flow dynamics in hydrocephalus, with and without aqueductal stenosis. Hydrocephalus is a neurological disorder which is characterized by enlarged brain ventricles. The periodic motion of CSF flow as a function of the cardiac cycle was prescribed as the inlet boundary condition at the foramen of Monro, and ETV was modeled as a 5 mm diameter hole in the anterior wall of the third ventricle. The results show that ETV reduces the pressure in the ventricles by nine-fold in the model with aqueductal stenosis, and three-fold in the model without aqueductal stenosis. More importantly, ETV changes the temporal characteristics of the CSF pressure waveform in the model without aqueductal stenosis, such that there is higher pressure in the ventricle during diastole. This study suggests that changes in the temporal characteristics of the CSF pressure waveform in the ventricles may be the reason why ETV treatment is not effective for hydrocephalus without aqueductal stenosis. |
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| Keywords: | Cerebrospinal fluid Cerebral ventricles Computational fluid dynamics Endoscopic third ventriculostomy Hydrocephalus |
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