Absence of seizures in Rasmussen encephalitis with active inflammation |
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| Institution: | 1. Neurology Section, Department of Pediatrics, University of Arkansas for Medical Sciences, 1 Children’s Way, Little Rock, AR 72202, USA;2. Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA;3. Division of Neurosurgery, Arkansas Children’s Hospital, and Department of Neurosurgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA;1. Department of Neurosurgery, University of Texas Health Science Center, 7703 Floyd Curl Drive, MC 7843, San Antonio, TX 78229, USA;2. School of Medicine, University of Texas Health Science Center, San Antonio, TX, USA;1. Department of Interventional Neuroradiology, Rothschild Foundation Hospital, 25 Rue Manin, 75019 Paris, France;2. Department of Neurosurgery, Rothschild Foundation Hospital, Paris, France;1. Department of Neurological Surgery, Houston Methodist Neurological Institute, 6560 Fannin Street, #944, Houston, TX 77030, USA;2. Bobby R. Alford Department of Otolaryngology–Head and Neck Surgery, Baylor College of Medicine, Houston, TX, USA;1. Department of Neurosurgery, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China;2. Department of Neurosurgery, Air Force General Hospital of the Chinese PLA, Haidian District, Beijing, China;3. Department of Anesthesiology, Beijing Military General Hospital, Beijing, China |
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| Abstract: | Severe focal motor epilepsy is considered a clinical hallmark of Rasmussen encephalitis (RE). The authors report a 6-year-old girl with progressive right sided hemiparesis, loss of language skills, left sided hemispheric atrophy, and brain pathologic features characteristic for RE. The patient did not experience seizures over a 2 year period after symptom onset and for several months during follow-up. This report expands the clinical spectrum of RE and suggests that seizures are not a universal symptom of RE. Our patient’s quite remarkable neurologic deficits along with active inflammation in the absence of epilepsy supports that, at least in some individuals, unilateral hemispheric progressive inflammation can occur without active seizure activity. |
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| Keywords: | Hemispheric atrophy Inflammation Progressive hemiparesis Rasmussen encephalitis |
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