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Pigmented ganglioglioma in a patient with chronic epilepsy and cortical dysplasia |
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| Institution: | 1. Department of Neurosurgery, Rush University Medical Center, 1725 W. Harrison St., Suite 855, Chicago, IL 60612, USA;2. Department of Pathology, Rush University Medical Center, Chicago, IL, USA;1. Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA;2. Department of Neurosurgery, Mayo Clinic, 200 First Street SW, Rochester, MN, USA;1. Department of Neurosurgery, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Meyer 5-185, Baltimore, MD 21287, USA;2. Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA;1. Department of Neurology, New York University School of Medicine, 240 East 38th Street, 20th Floor, New York, NY 10016, USA;2. Department of Population Health, New York University School of Medicine, New York, NY, USA;3. Department of Ophthalmology, New York University School of Medicine, New York, NY, USA |
| Abstract: | We report a rare case of a 22-year-old woman with biopsy-proven pigmented ganglioglioma. The patient initially underwent a right temporal lobectomy for intractable seizures at the age of 9 and remained seizure free for several years but subsequently developed complex partial seizures. Due to enhancement of a left mesial occipital lesion on preoperative MRI of the brain, the patient underwent a left subdural electrode placement and simultaneous biopsy of the left mesial occipital lesion. Biopsy results revealed a rare pigmented ganglioglioma, World Health Organization Grade I. The seizure focus was identified in the left mesial occipital lobe and the patient underwent tumor resection. An extensive literature search revealed that our patient is the fourth case of pigmented ganglioglioma described in the literature and was positive for BRAF V600E mutation by molecular studies. |
| Keywords: | Chronic epilepsy Cortical dysplasia Melanocytic melanogenesis Neuromelanin Pigmented ganglioglioma |
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