C-反应蛋白与冠状动脉病变严重程度相关的研究

目的 探讨C-反应蛋白（CRP）与冠状动脉病变严重程度的关系。方法 冠状动脉造影确定冠心病患者43例，其中稳定型心绞痛组20例，不稳定型心绞痛组23例，对照组20例，测定血清CRP浓度，冠状动脉病变程度采用Gensini积分。结果 CRP浓度在对照组、稳定型心绞痛组、不稳定型心绞痛组依次升高，两两比较差异均有显著性意义。血清CRP与冠脉Gensini积分呈正相关。结论 冠心病患者血清CRP浓度明显升高，CRP水平能反映患者病情及冠状动脉病变程度。

Research on the Relationship Between C-reactive Protein and Severity of Coronary Artery Disease

Objective To explore the relationship between C-reactive protein and severity of coronary artery disease. Methods 43 patients diagnosed with CHD by coronary angiography, 20 patients with stable angina, 23 with unstable angina.There were 20 normal controls who underwent coronary angiography and proved to exclude CHD. The serum CRP of CHD and control group was determined. The severity scale of coronary artery stenosis was assessed by Gensini score. Results The serum CRP concentrations were elevated in turn in the normal control group and the stable angina group, the unstable angina group.There were significant varieties between each other. The serum CRP concentrations were correlated positively with Gensini score. Conclusions The level of CRP is elevated in patients with coronary artery disease. CRP reflects the stability and severity of coronary artery disease.