T细胞受体信号转导通路的动力学分析

目的:建立T细胞受体信号转导途径的动力学模型,通过模型仿真揭示T细胞受体信号途径各分子间的动态调控过程,简要分析模型的动力学特性。方法:根据数据库KEGG及相关中英文文献,提取T细胞受体信号转导各条通路相关分子作用的方式及数量关系,利用Matlab7.0的Simulink工具箱构建信号途径的动力学模型并仿真。结果:模型仿真结果与文献符合得较好,能够从数量上反映T细胞受体信号转导途径中各分子间复杂的调控关系,并能通过模型仿真发现和验证该信号途径中的关键节点分子。结论:模型基本反映了T细胞受体信号转导途径的动力学特征,可以作为后续的精确定量关系研究的基础。

Dynamic Analysis of T Cell Receptor Signaling Pathway

Objective： To develop and simulate a dynamic model dealing with the quantitatively regulatory relationship between interacting molecules involved in T cell receptor signaling pathway and analyze the dynamic traits of the model. Methods： Based on KEGG database and related literatures in English and Chinese, the interaction mode and quantitative relationship of the related molecules involved in T cell receptor signaling pathway were extracted. By using ＂Simulink＂ toolbox of Matlab7.0, a dynamic model of T cell receptor signaling pathway was developed and simulated. Results： Model simulation results were in accord with the literatures, and can reflect quantitatively the complex regulatory relationship between interacting molecules involved in T cell receptor signaling pathway. In addition, model simulation can help us find and identify the key molecule in this signaling pathway. Conclusion： The model has generally reflected the dynamic characteristics of T cell receptor signaling pathway,and can be used as the basis for the follow-up study on the precise quantitative relationship.