Different kinetics of lung clearance of technetium-99m labelled diethylene triamine penta-acetic acid in patients with sarcoidosis and smokers |
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Authors: | Ingela Brådvik Per Wollmer Eva Evander Hildur Lárusdóttir Berith Blom-Bülow Björn Jonson |
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Institution: | (1) Department of Lung Medicine, University Hospital, Lund, Sweden;(2) Department of Clinical Physiology, Malmö General Hospital, Malmö, Sweden;(3) Department of Clinical Physiology, University Hospital, Lund, Sweden;(4) Department of Diagnostic Radiology, University Hospital, Lund, Sweden;(5) Department of Lung Medicine, University Hospital, S-221 85 Lund, Sweden |
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Abstract: | The rate of clearance from the lungs of inhaled technetium-99m labelled diethylene triamine penta-acetic acid (99mTc-DTPA) is often increased in interstitial lung disease as well as in smoking. In smokers a bi-exponential clearance course of 99mTc-DTPA when measured over 3 h has previously been shown. This study was performed to compare the kinetics of clearance of 99mTc-DTPA, measured for 3 h, in sarcoid patients and healthy smokers. Forty-one never-smoking patients with sarcoidosis and radiological signs of intrathoracic disease were studied. The results were compared with those of 16 healthy current smokers and of 14 healthy never-smokers reported previously. A mono-exponential clearance equation described the clearance in 22 of the sarcoid patients and all normal never-smokers, but with a shorter average tracer half-life in the patients (P<0.05). In 19 patients and all smokers a bi-exponential equation gave a significantly better curve fit. The rate of clearance of the slow component was higher in patients with sarcoidosis than in smokers (P< 0.05). The fraction of the tracer cleared by the fast clearance component was smaller in patients with sarcoidosis than in smokers (P<0.01). Differences in kinetics of clearance of 99mTc-DTPA in sarcoidosis and smoking could thus be demonstrated, suggesting that the abnormal clearance is caused by diverging pathophysiological mechanisms. |
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Keywords: | Lung function Radionuclide imaging Smoking Technetium-99m diethylene triamine pentaacetic acid |
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