合并睡眠呼吸暂停低通气综合征的老年慢性阻塞性肺病患者的临床特点分析

目的分析慢性阻塞性肺疾病（COPD）合并阻塞性睡眠呼吸暂停低通气综合征（OSAHS），即重叠综合征患者睡眠呼吸紊乱的临床特点，比较门诊和住院COPD患者的呼吸紊乱情况。方法对Epworth嗜睡量表评分≥10，夜间氧减饱和指数ODI4（每小时血氧饱和度下降4％的次数）≥5的门诊及住院稳定期300例COPD患者进行多导睡眠图监测。结果住院COPD患者的呼吸紊乱程度更严重，住院与门诊COPD合并OSAHS患者在体重指数、血氧饱和度低于90％的时间占总记录时间的百分比、夜间平均血氧饱和度、夜间最低血氧饱和度、呼吸紊乱指数等方面差异显著。此外，住院COPD患者睡眠中心率增快。结论睡眠呼吸紊乱可以影响并加重COPD患者病情。

Clinical features of elderly patients with chronic obstructive pulmonary disease and obstructive sleep apnea-hypopnea syndrome

Objective To analyze the clinical features of chronic obstructive pulmonary disease （COPD） patients with or without obstructive sleep apnea-hypopnea syndrome （OSAHS） （overlap syndrome）, and compare the status of sleep-disorder breathing between outpatients and inpatients of them. Methods A total of 300 patients with stable COPD were screened for sleep disorder breathing using questionnaire, Epworth sleepiness scale （ESS） and home pulse oximeter testing. Those with ESS≥10 or oxygen desaturation over 4% per hour sleep 〉5 times were under further PSG testing. Results there was significant difference on sleep-disordered breathing index, body mass index, heart rate in sleep, the percentage of the recording time spent with arterial oxygen saturation（SIT90） , the nocturnal mean arterial oxygen saturation and the minimal arterial oxygen saturation between COPD outpatients and inpatients clinics. Conclusion Sleep-disordered breathing can affect and aggravate patients condition of COPD.