| 局部亚低温对胆红素脑病仔兔脑基底节中多巴胺及5-羟色胺的影响 |
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| 引用本文： | 王丽梅,郝艳秋,石丽宏. 局部亚低温对胆红素脑病仔兔脑基底节中多巴胺及5-羟色胺的影响[J]. 中国康复理论与实践, 2010, 16(1): 35-37 |
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| 作者姓名： | 王丽梅 郝艳秋 石丽宏 |
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| 作者单位： | 1.哈尔滨医科大学附属五院康复科，黑龙江大庆市 163318；2.哈尔滨医科大学附属二院儿科，黑龙江哈尔滨市 150086。 |
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| 摘 要： | 目的观察局部亚低温不同时间窗，胆红素脑病仔兔脑基底节区多巴胺（DA）及5-羟色胺（5-HT）含量的变化。方法建立胆红素脑病模型，对治疗组予亚低温治疗，采用荧光分光光度法，检测治疗后不同时间窗胆红素脑病仔兔脑基底节中DA及5-HT含量。结果胆红素脑病组仔兔脑基底节中DA及5-HT含量于造模后明显降低（P＜0.01）。治疗6 h、12 h、24 h后，DA及5-HT含量均明显升高（P＜0.01）。结论局部亚低温可明显减轻胆红素脑病脑组织中DA、5-HT的代谢紊乱，对脑组织具有治疗及保护作用。亚低温时间越长，效果越好。
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| 关 键 词： | 胆红素脑病 亚低温 多巴胺 5-羟色胺 |
| 收稿时间： | 2009-11-24 |
Effects of Local Mild Hypothermia on Dopamine and 5-Hydroxytryptamine in Basal Ganglion of Neonatal Rabbits with Bilirubin Encephalopathy |
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| WANG Li-mei,HAO Yan-qiu,SHI Li-hong. Effects of Local Mild Hypothermia on Dopamine and 5-Hydroxytryptamine in Basal Ganglion of Neonatal Rabbits with Bilirubin Encephalopathy[J]. Chinese Journal of Rehabilitation Theory and Practice, 2010, 16(1): 35-37 |
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| Authors: | WANG Li-mei HAO Yan-qiu SHI Li-hong |
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| Affiliation: | Department of Rehabilitation Medicine，The Fifth Affiliated Hospital of Harbin Medical University，Daqing 163318，Heilongjiang， china |
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| Abstract: | Objective To observe the effects of local mild hypothermia at different time on dopamine (DA) and 5-hydroxytryptamine (5-HT) concentration in rabbits brain basal ganglion with bilirubin encephalopathy.Methods The model of bilirubin encephalopathy was established,and treated with mild hypothermia for different time.The DA and 5-HT in the basal ganglion were detected with fluorescence spectrophotometry.Results The DA and the 5-HT decreased in the basal ganglion significantly after modeling (P<0.01),and increa... |
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| Keywords: | bilirubin encephalopathy mild hypothermia dopamine 5-hydroxytryptamine |
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