Some arylacridine derivatives possessing potassium channel opening activity |
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Authors: | Simşek Rahime Ozkan Melike Kismetli Emrah Uma Serdar Safak Cihat |
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Affiliation: | Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey. |
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Abstract: | In this study, six new 2,2,7,7-tetramethyl-9-aryl-2,3,4,5,6,7,9,10-octahydro-1,8-acridinedione derivatives (1-6) were synthesised and their functional effects on vascular potassium channels and mechanism of induced relaxations on phenylephrine-induced contractile responses in isolated rat mesenteric arteries were investigated. Pinacidil was used as standard potassium channel opener. Compounds 1, 2, 5, 6 and pinacidil induced concentration-dependent relaxation response of vessel rings previously contracted with phenylephrine. |
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Keywords: | Potassium channel openers Acridinedione Synthesis |
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