NoD／SCID小鼠在实验血液学研究中的应用

NOD／SCID（非肥胖糖尿病／重症联合免疫缺陷）小鼠是在SCID（重症联合免疫缺陷）小鼠的基础上与非肥胖性糖尿病小鼠（NOD／Lt）品系回交的免疫缺陷鼠。NOD／SCID小鼠既有先天免疫缺陷，又有T和B淋巴细胞缺乏，各种肿瘤细胞可以植入，且较少发生排斥反应及移植物抗宿主病（GVHD），所以NOD／SCID小鼠逐渐成为血液学实验研究的有用工具。本文从NOD／SCID小鼠的生物学特性及其在建立人类白血病模型、干细胞移植、药物研究及NOD／SCID小鼠应用中存在的不足和改良等方面综合述评。

Application of NOD/SCID Mice in Research of Experimental Hematology-Review

NOD/SCID (non-obese diabetic/severe combined immunodeficient) mice are immune deficient mice which are made by backcross of severe combined immunodeficient mice with non-obese diabetic mice strains. NOD/SCID mice are both innate immune deficiencies and lack of T and B lymphocytes. Various tumor cells can be implanted in this kind of mice, the rejection and graft-versus-host disease (GVHD) occur fewer. Therefore, NOD/SCID mice gradually become a useful tool for the study on Experimental Hematology. This paper comprehensively reviews the biological characteristics of NOD/SCID mice, the establishment of human leukemia model, stem cell transplantation, drug research, deficiency and improvement of NOD/SCID mice in application for study.