血管内皮生长因子及受体对妊娠高血压综合征发病的影响

目的:探讨血管内皮生长因子(VEGF)及受体(FLT-1)在妊娠高血压综合征(妊高征)发病中的作用。方法:选取妊高征孕妇51例,正常妊娠妇女44例(其中晚期妊娠23例),及非妊娠妇女10例为研究对象。采用ELISA方法测定其血清VEGF水平;以免疫组织化学方法观察VEGF及受体FLT-1在胎盘绒毛中的表达。结果:妊高征组血清VEGF水平为23.39±9.79ng/L,明显低于正常晚期妊娠组(40.62±14.85ng/L),(P<0.01)。胎盘中VEGF及肿-1的表达较正常晚期妊娠组弱,有显著性差异(P<0.05)。轻度妊高征组血清VEGF水平为33.79±5.97ng/L,与正常晚期妊娠组比较无明显差异(P>0.05)。中、重度妊高征组VEGF水平分别为21.44±2.07ng/L、16.45±5.56ng/L,与晚期妊娠组比较,差异有显著性(P<0.01)。结论:孕妇血清中VEGF水平下降、胎盘中VEGF及FLT-1表达降低可能与妊高征的发病机理有关。

The role of vascular endothelial growth factor and its receptor in the genesis of pregnancy-induced hypertension

Objective:To find out the role of vascular endothelial growth factor and FLT-1 in the genesis of pregnancy-induced hypertension (PIH) .Methods:51 women with PIH,44 normal pregnant women including 23 third trimester cases and 10 healthy non-pregnant women were investigated . Serum concentrations of VEGF were evaluated by ELISA. Expression of VEGF and its receptors FLT-1 in placental villi were measured by immunohistochemistry. Results: 1. Serum levels of VEGF were lower in PIH group(23.39 ± 9.79ng/L) than that in third trimester pregnancy group (40.62± 14.85ng/L) (P < 0.01). The expressions of VEGF and its receptor FLT-1 in the placenta of PIH group were reduced than that in third trimester pregnancy group ( P < 0.05 ) . There is no difference between the serum levels of VEGF in mild Pffl (33.79 ± 5.97ng/L) and the third trimester group( P > 0 . 05) . The serum levels of VEGF in moderate and severe PIH( 21 . 44 ± 2 . 07ng/L, 16.45 ± 5.56ng/L) were significantly lower than that in third trimester( P < 0.01). Conclusions: The decreased serum levels of VEGF and the reduced expression levels of VEGF, FLT-1 in placental tissues might play an important role in the pathogenesis of PIH.