| 枇杷叶三萜酸降血糖活性实验研究 |
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| 引用本文： | 李锋,王航,薛原楷,郭养浩. 枇杷叶三萜酸降血糖活性实验研究[J]. 药物生物技术, 2011, 0(4): 328-331 |
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| 作者姓名： | 李锋 王航 薛原楷 郭养浩 |
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| 作者单位： | 福州大学生物科学与工程学院;福建省医疗器械与医药技术重点实验室; |
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| 基金项目： | 福建省医疗器械与医药技术重点实验室开放基金项目(09004); 福建省自然科学基金项目(2008J0293); 福州大学科技基金项目(2008-XY-18) |
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| 摘 要： | 以格列齐特和盐酸二甲双胍为阳性对照药物,研究枇杷叶三萜酸提取物对正常小鼠空腹血糖值的影响、对正常小鼠经口葡萄糖和淀粉耐受的影响以及对糖尿病小鼠血糖的影响。结果与格列齐特相比(100 mg/kg),枇杷叶三萜酸提取物对正常小鼠的空腹血糖无明显影响(P>0.05);与格列齐特(100 mg/kg)相比,枇杷叶三萜酸提取物对四氧嘧啶所致高血糖模型小鼠的血糖值的抑制效果不明显(P>0.05);枇杷叶三帖酸粗提物(CTAL,400 mg/kg)对正常小鼠空腹灌胃葡萄糖后的血糖上升有明显的抑制作用(P<0.01),抑制效果与盐酸二甲双胍(100 mg/kg)相当,而枇杷叶科罗索酸(CAL)对此抑制活性不明显(P>0.05);枇杷叶三帖酸粗提物(CTAL,400 mg/kg)对正常小鼠空腹灌胃淀粉后的血糖上升有较强的抑制作用(P<0.01),抑制效果强于盐酸二甲双胍(100 mg/kg),而枇杷叶科罗索酸(CAL,400 mg/kg和100 mg/kg)也显示较好抑制作用(P<0.05)。枇杷叶提取物体现出较好的控制餐后血糖的活性且不对正常机体的血糖值造成影响,具有开发成减肥产品或相关药物的良好的前景。
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| 关 键 词： | 枇杷叶 三萜酸 科罗索酸 降血糖 |
The Experimental Study on Hypoglycemic Activity of Triterpenic Acids from Loquat Leaf |
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| LI Feng,,WANG Hang,XUE Yuan-kai,GUO Yang-hao. The Experimental Study on Hypoglycemic Activity of Triterpenic Acids from Loquat Leaf[J]. Pharmaceutical Biotechnology, 2011, 0(4): 328-331 |
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| Authors: | LI Feng WANG Hang XUE Yuan-kai GUO Yang-hao |
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| Affiliation: | LI Feng1,2,WANG Hang1,XUE Yuan-kai1,GUO Yang-hao2(1.School of Bioscience and Bioengneering,Fuzhou University,Fuzhou 350108,China,2.Fujian Key Laboratory of Medical Devices and Pharmaceautical Technology,Fuzhou 350002,China) |
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| Abstract: | To investigate typoglycemic activity with triterpene acid extracted from loquat leaf.Using gliclazide and metformin hydrochloride as the positive control,the influences of loquat leaf triterpenic acids extracts(LTAE) on fasting blood glucose levels of normal mice were investigated;the influences of LTAE on glucose and starch tolerance of normal taken orally and the influences ofLTAE on blood glucose levels of diabetic mice were all investigated.Compared with gliclazide(100 mg/kg,P <0.01),crude triterpenic a... |
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| Keywords: | loquat leaf triterpenic acid corosolic acid hypoglycemic activity |
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