吗啡和电针对伤害性刺激诱发体感皮层单位放电的时锁和非时锁反应的影响

<正> 过去研究电针对痛敏单位放电的影响时,大多数报道都以非时锁反应(单位时时内放电数量或平均放电率的变化)为指标,也有用时锁反应(对刺激有效固定的时间关系的短暂反应)为指标。我们对这两种反应进行了对比,两者反映角度不完全相同。本文以伤害性刺激猫的腓浅神经(PN)诱发

Effects of morphine and electro-acupuncture on the time lock and not-time lock responses of cortical unit discharges evoked by nociceptive stimulation in cats

In order to study the effects of morphine and electro-acupuncture(EA) on non-time-lock response (N-TLR) and time-lock respone (TLR) of nociceptive unit discharges. N-TLR was shown by interspike interval mean function (ISIMF) and TLR by normalized cross-covariance function (NCCVF) reflecting the relationship between stimulation and response. The results showed that the N-TLR elicited by the noxious stimulation appeared as a decrease of ISIMF. Which was depressed obviously by EA and morphine, but inhibitory effect of EA was more rapid than morphine, that both EA and morphine inhibited mainly the late peak of the NCCVF elicited by the noxious stimulation, but inhibitory effect of EA was more rapidly developing and more quickly recovering than that of morphine. The inhibitory effect of EA on the early peak was very little. From above results it was suggested that the P-ED elicited by the noxious stimulation could be inhibited by both EA and morphine, but the degree and the speed of inhibition were difference.