| Preparation and Evaluation in Vitro of BCNU-Loaded PLA Nanoparticles |
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| 作者姓名： | GUOYan-shuang YUANXu-bo LIUXiao-yan LUJian CHANGJin KANGChun-sheng PUPei-yu |
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| 作者单位： | [1]InstitutionofNanobiotechnology.SchoolofMaterial.TianjinUniversity.Tianjin300072,China [2]TianjiuMedicalUniversity.Tianjin300070.China,China [3]InstitutionofNanobiotechnology.SchoolofMaterial.TianjinUniversity.Tianjin300072,China |
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| 基金项目： | National NatureScience Foundation( No.5 0 30 10 0 8),National Key basic researchProgram( No.2 0 0 1CCC0 14 0 0 ),TianjinNatureScience Foundation( No.0 136 16 6 11) |
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| 摘 要： | In this study, using a spontaneous emulsification/solvent extraction method, BCNU-Ioaded PLA nanoparticles (NPs) with small particle size and narrow size distribution have been acquired. The particle size of the NPs ranged from 40-60 nm and 100-200 nm according to different requirements. SEM and TEM showed that the particle size considerably decreases with increasing emulsification concentration and decreasing PLA concentration and ratio of oil to water. The highest drug loading ratio and drug encapsulation efficiency of NPs were 5. 63% and 33.45%. The results demonstrated that decrease of initial BCNU content resuited in a noticeably increased encapsulation yield. A thorough study in vitro showed that the drug could be steadily released from NPs for one week. In addition, drug-loaded NPs had higher antitumor activity, compared with free BCNU,and sustained drug release characteristics as well.
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| 关 键 词： | 卡氮芥 药物微粒 用药途径 药物释放 肿瘤 药物治疗 |
Preparation and Evaluation in Vitro of BCNU-Loaded PLA Nanoparticles |
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| GUOYan-shuang YUANXu-bo LIUXiao-yan LUJian CHANGJin KANGChun-sheng PUPei-yu.Preparation and Evaluation in Vitro of BCNU-Loaded PLA Nanoparticles[J].Chinese Journal of Biomedical Engineering,2004,13(3):110-117. |
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| Authors: | GUO Yan-shuang YUAN Xu-bo LIU Xiao-yan LU Jian CHANG Jin KANG Chun-sheng PU Pei-yu Institution of Nanobiotechnology School of Material Tianjin University Tianjin China Tianjin Medical University Tianjin China |
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| Institution: | GUO Yan-shuang 1,YUAN Xu-bo 1,LIU Xiao-yan 1,LU Jian 1,CHANG Jin 1,KANG Chun-sheng 2,PU Pei-yu 21 Institution of Nanobiotechnology,School of Material,Tianjin University,Tianjin 300072,China 2 Tianjin Medical University,Tianjin 300070,China |
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| Abstract: | In this study,using a spontaneous emulsification/solvent extraction method,BCNU-loaded PLA nanoparticles (NPs) with small particle size and narrow size distribution have been acquired. The particle size of the NPs ranged from 40~60 nm and 100~200 nm according to different requirements. SEM and TEM showed that the particle size considerably decreases with increasing emulsification concentration and decreasing PLA concentration and ratio of oil to water. The highest drug loading ratio and drug encapsulation efficiency of NPs were 5.63% and 33.45%. The results demonstrated that decrease of initial BCNU content resulted in a noticeably increased encapsulation yield. A thorough study in vitro showed that the drug could be steadily released from NPs for one week. In addition,drug-loaded NPs had higher antitumor activity,compared with free BCNU,and sustained drug release characteristics as well. |
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| Keywords: | Drug delivery system BCNU PLA Nanoparticle Controlled release Cancer therapy |
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