原发性高血压和冠心病患者胰岛素和C-肽的临床观察

目的：观察原发性高血压（EH）和冠心病（CHD）患者的胰岛素抵抗及其差异。方法：检测原发性高血压（EH）52例，冠心病（CHD）47例和健康对照组35例的空腹和服糖2h后胰岛素和C-肽，并进行比较。结果：原发性高血压病人和冠心病人空腹及服糖后2h血糖、胰岛素和C-肽明显高于正常健康人（P〈0.01）。结论：原发性高血压和冠心病患者存在胰岛素抵抗、高胰岛素血症、高C-肽水平。

Observations on the Presence of Insulin Resistance in Patients with Essential Hypertension and Coronary Heart Disease

Objective To investigate the presence of insulin resistance in patients with essential hypertension(EH) and coronary heart disease(CHD).Methods Fasting and 2h post oral 75g glucose blood sugar(with oxidase method),insulin and C-peptide(with RIA) levels were examined in 52 patients with EH,40 patients with CHD and 35 controls.Results The fasting and 2h post oral glucose serum levels of glucose,insulin and C-peptide in the patients were significantly higher than those in the controls(P<0.01),suggesting presence of impaired glucose tolerance and insulin resistance.Conclusion Impaired glucose tolerance due to insulin resistance was demonstrated in the studied patients with EH or CHD.