单核细胞趋化蛋白-1在糖尿病视网膜病变中的作用研究进展

糖尿病视网膜病变（DR）是糖尿病最为常见和严重的并发症之一，是成年人视力丧失的主要原因。越来越多的证据表明，炎症在DR的发病机制中发挥关键作用，抗炎治疗或许能有效延缓DR的发生和发展。单核细胞趋化蛋白-1 （MCP-1）作为炎症反应过程中一种重要的趋化因子，通过趋化和激活因子、破坏血视网膜屏障、引起视网膜血管病变、激活...

Research progress in the role of monocyte chemoattractant protein-1 in diabetic retinopathy

Diabetic retinopathy(DR)is one of the most common and serious diabetic complications,which is the main cause of vision loss in adults.The specific vascular and neuropathology mechanism of DR is not clear.It has been demonstrated that Inflammatory reaction might be take effects in the development and progression of DR.Monocyte chemoattractant protein-1(MCP-1),as an important chemokine in the inflammatory response process,promotes chemotactic and activating factors,destroys the blood-retinal barrier,causes retinal vascular disease,and activates microglia,which is related to the severity of the disease.With further research on MCP-1,it is possible to use chemokines and their receptors as target cells to control or slow down the progression of DR by reducing or inhibiting the production of MCP-1 in diabetic patients in the early stages of the disease.This study can provide new ideas and new methods about preventing and treating DR.